Клинический вестник ФМБЦ им. А.И. Бурназяна

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Федеральный медицинский биофизический центр имени А.И.Бурназяна»

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Выпуск №2 2025 год

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ВНИМАНИЮ АВТОРОВ СТАТЕЙ

Клинический вестник ФМБЦ им. А.И. Бурназяна. 2024. № 4

Л.С. Бутаев1,2, Ю.А. Олейник1, Жеребцова В.А.1, М.П. Булусов1, А.Ю.Субора1, А.М. Сухарева1,
Е.С.Урнова1, Д.Г. Кисиличина1, В.В.Птушкин1, Т.А. Астрелина2, А.С. Самойлов2

ПРИМЕНЕНИЕ ПРЕПАРАТА ВЕНЕТОКЛАКС В ТЕРАПИИ У ПАЦИЕНТОВ
С РЕЦИДИВОМ ИЛИ РЕФРАКТЕРНЫМ ТЕЧЕНИЕМ В-КЛЕТОЧНЫХ ЛИМФОМ
(ОПЫТ ГБУЗ ММНКЦ ИМ. С.П. БОТКИНА ДЗМ)

1ГБУЗ ММНКЦ им. С.П. Боткина ДЗМ

2ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России, Москва

Контактное лицо: Астрелина Татьяна Алексеевна: t_astrelina@mail.ru

Резюме
Пациенты с рецидивом или рефрактерным течением (р/р) ДВККЛ, первичной медиастинальной В-ККЛ и с ранним рецидивом (до 2 лет) ФЛ имеют плохой прогноз и короткую общую выживаемость. Стандартная ПХТ II линии для пациентов младше 60-65 лет с р/р ДВККЛ включает курсы интенсивной ПХТ с препаратами платины и аутотрансплантацию стволовыми клетками (ТСКК). Известно, что ответ на терапию достигается только у половины больных на фоне стандартной химиотерапии. Добавление новых таргетных препаратов может улучшить результаты лечения. В данной работе представлены первые результаты добавления препарата Венетоклакса к химиотерапии у пациентов с р/р агрессивных В-клеточных лимфом.

Ключевые слова: венетоклакс, рецидив или рефрактерное течение В-клеточных лимфом, выживаемость, полная ремиссия

Для цитирования: Бутаев Л.С., Олейник Ю.А., Жеребцова В.А., Булусов М.П., Субора А.Ю., Сухарева А.М., Урнова Е.С., Кисиличина Д.Г., Птушкин В.В., Астрелина Т.А., Самойлов А.С. Применение препарата венетоклакс в терапии у пациентов с рецидивом или рефрактерным течением в-клеточных лимфом (опыт гбуз ммнкц им. С.П. Боткина ДЗМ) // Клинический вестник ФМБЦ им. А.И. Бурназяна 2024. №4. С. 25–33. DOI: 10.33266/2782-6430-2024-4-25-33

 

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Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.
Финансирование. Исследование не имело спонсорской поддержки. 
Участие авторов. Cтатья подготовлена с равным участием авторов.
Поступила: 13.05.2024. Принята к публикации: 11.06.2024. 

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