Клинический вестник ФМБЦ им. А.И. Бурназяна. 2023. № 4
Е.А.Дубова, К.А.Павлов
ОСОБЕННОСТИ ПАТОМОРФОЛОГИЧЕСКОГО ИССЛЕДОВАНИЯ ПРОТОКОВОЙ
АДЕНОКАРЦИНОМЫ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ ПОСЛЕ НЕОАДЪЮВАНТНОЙ ТЕРАПИИ
ФГБУ «Государственный научный центр – Федеральный медицинский биофизический центр им. А.И.Бурназяна» ФМБА России, Москва, Россия
Контактное лицо: Дубова Елена Алексеевна: dubovaea@gmail.com
Резюме
Протоковая аденокарцинома поджелудочной железы – агрессивная опухоль с плохим прогнозом и низкой выживаемостью. Основным методом лечения является радикальная операция. В настоящее время в схемах лечения пациентов с потенциально резектабельной протоковой аденокарциномой поджелудочной железы используют предоперационную неоадъювантную терапию. В связи с этим возникает необходимость морфологической оценки степени регресса опухоли патологом. До сих пор не существует международно признанных согласительных руководств по патологоанатомической оценке образцов панкреатэктомии после неоадъювантной терапии. В данном обзоре обобщены имеющиеся литературные данные по макроскопическому и микроскопическому исследованию протоковой аденокарциномы поджелудочной железы после неодъювантной терапии, а также о прогностической значимости определения патологоанатомической стадии, оценки ответа опухоли на терапию и других морфологических параметров.
Ключевые слова: поджелудочная железа, протоковая карцинома, неоадъювантная терапия, регресс опухоли
Для цитирования: Дубова Е.А., Павлов К.А. Особенности патоморфологического исследования протоковой аденокарциномы поджелудочной железы после неоадъювантной терапии // Клинический вестник ФМБЦ им. А.И. Бурназяна. 2023. №4. С.19–25. DOI: 10.33266/2782-6430-2023-4-19-25
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Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.
Финансирование. Исследование не имело спонсорской поддержки.
Участие авторов.
Дубова Е.А. – анализ литературных данных, написаниетекстастатьи
Павлов К.А. – редактирование текста, утверждение итогового варианта текста рукописи
Поступила: 29.11.2023. Принята к публикации: 15.12.2023.