Клинический вестник ФМБЦ им. А.И. Бурназяна. 2022. № 3
Е.И. Толстых1, П.А. Шарагин1, Е.А. Шишкина1,2, А.Ю. Волчкова1, М.О. Дёгтева1
АНАТОМО-МОРФОЛОГИЧЕСКИЙ БАЗИС ДЛЯ ДОЗИМЕТРИЧЕСКОГО
МОДЕЛИРОВАНИЯ ТРАБЕКУЛЯРНОЙ КОСТИ ЧЕЛОВЕКА С ИСПОЛЬЗОВАНИЕМ
СТОХАСТИЧЕСКОГО ПАРАМЕТРИЧЕСКОГО ПОДХОДА
1Уральский научно–практический центр радиационной медицины, ФМБА России, Челябинск
2Челябинский государственный университет, Челябинск
Контактное лицо: Толстых Евгения Игоревна: evgenia.tolstykh@yandex.ru
Резюме
Цель: Создать анатомо-морфологическую основу для стохастической параметрической скелетной дозиметрической модели (SPSD-модели) человека различного возраста, которая включает оценку параметров микроструктуры трабе- кулярной кости в кроветворных участках скелета человека. Модель необходима для оценок доз на красный костный моз от остеотропных радионуклидов (89,90Sr). Модель создается в рамках дозиметрической поддержки эпидемиоло- гических исследований Южно-Уральских когорт, члены которых проживали на территориях, подвергшихся радио- активному загрязнению 1950-х годах.
Материалы и методы: Оценка модельных параметров базируется на сборе и анализе опубликованных данных. Отбор публикаций производили с использованием поисковых систем Интернета: Google, PubMed, Academia, e-library и т.п. Отбирались оригинальные статьи в рецензируемых изданиях, рассматривались атласы, руководства, монографии и диссертации. Собиралась информация только о здоровых лицах. Информация касалась оценки следующих параметров трабекулярной кости: толщина трабекул, межтрабекулярное пространство, доля кости в общем объеме ткани, которые оценивались методами гисто-морфометриии и микро-КТ. Для принятия решения о моделировани кости рассматривали данные об активности кроветворения в ней, полученные методом МРТ и ПЭТ.
Результат: По результатам анализа опубликованной информации были сформированы файлы первичных данных, со- держащих библиографические данные об источнике информации, данные о субъектах исследования и результатах из- мерений параметров трабекулярной кости. На этой основе были получены средне-популяционные оценки параметров и оценена их вариабельность (стандартное отклонение, коэффиценты вариации). Были проанализированы данные о длительности кроветворения в различных частях скелета и данные о возрастных изменениях микроструктуры. В работе представлено описание полного набора параметров SPSD-модели трабекулярных костей для новорожденных, детей в возрасте 1, 5 и 10 лет, а также для подростков в возрасте 15 лет и взрослых.
Заключение: Полученные численные значения используются в качестве входных данных (параметров) для генериро- вания дозиметрических фантомов в воксельной форме. Наши результаты позволят в будущем расчитывать коэффици- енты конвертации, связывающие удельную активность радионуклидов в ткани-источнике (костные трабекулы) и мощность дозы в ткани-детекторе (красный костный мозг), а также неопределенность этих оценок.
Ключевые слова: Дозиметрия, стохастическое моделирование, скелет, красный костный мозг, трабекулярная кость
Для цитирования: Толстых Е.И., Шарагин П.А., Шишкина Е.А., Волчкова А.Ю., Дёгтева М.О. Анатомо-морфологический базис для дозиметрического моделирования трабекулярной кости человека с использованием стохастического параметрического подхода//Клинический вестник ФМБЦ им. А.И. Бурназяна 2022. № 3. С. 25–40. DOI: 10.33266/2782-6430-2022-3-25-40
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Поступила: 13.08.2022. Принята к публикации: 28.08.2022.