A.I. BURNASYAN FMBC CLINICAL BULLETIN

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №1, 2026

more

A.I. Burnasyan  FMBC clinical bulletin. 2025 № 4

N.V. Rylova, S.V. Gornov., V.S. Nopina

Nutritional Factors of Osteoarthritis Prevention

International Office, State Research Center – Burnasyan Federal Medical Biophysical Center  of Federal Medical Biological Agency, Moscow, Russiа

Contact person: Rylova Natal’ya Victorovna: rilovanv@mail.ru

 

Abstract
The analysis of data from domestic and foreign literature devoted to the nutritional aspects of osteoarthritis prevention has been carried out. The world experience in the use of pharmacornutrients – collagen, chondroitin sulfate as monotherapy and in combination with other methods is summarized on this topic. The search was conducted using the electronic databases Pubmed, MEDLINE, Embase, Scopus, eLibrary for the period from 1999 to 2024. For the search, we used keywords and their combinations: “collagen”, “chondroitin sulfate”, “treatment of osteoarthritis”, “prevention of osteoarthritis”. According to the results of the study, pharmaconutrients containing collagen or chondroitin sulfate have a positive effect on the prognosis of patients suffering from osteoarthritis, as well as improve their quality of life.

Keywords: collagen, chondroitin sulfate, osteoarthritis treatment, osteoarthritis preventions

For citation: Rylova NV, Nopina VS. Nutritional Factors of Osteoarthritis Prevention. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2025.4:05-09. (In Russian) DOI: 10.33266/2782-6430-2025-4-05-09

 

REFERENCES

  1. Olyunin Yu.A., Nikishina N.Yu. Osteoarthritis: Key Links in Pathogenesis and Modern Means of Pathogenetic Therapy. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2017;11;3:121-128 (In Russ). doi: 10.14412/1996-7012-2017-3-121-128.
  2. Savarina V.A. Neuropathic Pain in Osteoarthritis. Molodezhnyy Sbornik Nauchnykh Statey «Nauchnyye Stremleniya» = Scientific Aspirations. 2018;23:57-58 (In Russ). doi: 10.31882/2311-4711.2018.23.13.
  3. Filatova Ye.S., Lila A.M. Contribution of Neurogenic Mechanisms to the Pathogenesis of Chronic Joint Pain. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2021;2:43-49 (In Russ.). doi: 10.14412/1996-7012-2021-2-43-49.
  4. Khitrov N.A. Osteoarthrosis and Osteoarthritis – from New Views on Pathogenesis to a New Name. Meditsinskiy Sovet = Medical Council. 2013;4:74-78 (In Russ.). doi: 10.21518/2079-701X-2013-4-74-78.
  5. Nasonova V.A. Osteoarthrosis – the Problem of Polymorbidity. Consilium Medicum. 2009;11;2: 5-8 (In Russ).
  6. Korshunov N.I., Rechkina Ye.V., Filatova Yu.S., Yal’tseva N.V. Osteoarthritis and Depression. Nauchno-Prakticheskaya Revmatologiya = Scientific and Practical Rheumatology. 2018;1:93-98 (In Russ.). doi: 10.14412/1995-4484-2018-93-98.
  7. Rehman Q., Lane N.E. Getting Control of Osteoarthritis Pain. An Update on Treatment Options. Postgrad Med. 1999 Oct 1;106;4:127-34. doi: 10.3810/pgm.1999.10.1.707. PMID: 10533513.
  8. Samoylov A.S., Rylova N.V., Simonov R.A. Use of PRP Therapy for Osteoarthritis of the Knee Joint in Clinical and Sports Medicine: a Literature Review. Klinicheskiy Vestnik FMBTS im. A.I. Burnazyana = Clinical Bulletin of the A.I. Burnazyan Federal Medical and Biophysical Center. 2023;2:5–12 (In Russ.). doi: 10.33266/2782-6430-2023-2-05-12.
  9. Yaremenko O.B., Anokhina G.A., Bur’yanov A.A. Joint. Cartilage. Collagen. Travma = Trauma. 2020;21;4:6-12 (In Russ.).
  10. Thomas D.T., Prabhakar A.J., Eapen C., et al. Comparison of Single and Combined Treatment with Exercise Therapy and Collagen Supplementation on Early Knee Arthritis among Athletes-A Quasi-Randomized Trial. Int J Environ Res Public Health. 2023 Nov 21;20;23:7088. doi: 10.3390/ijerph20237088. PMID: 38063519. PMCID: PMC10706409.
  11. Carafoli F., Bihan D., Stathopoulos S., et al. Crystallographic Insight into Collagen Recognition by Discoidin Domain Receptor 2. Structure. 2009 Dec 9;17;12:1573-81. doi: 10.1016/ j.str.2009.10.012.
  12. Vogel W.F., Abdulhussein R., Ford C.E. Sensing Extracellular Matrix: an Update on Discoi-Din Domain Receptor Function. Cell Signal. 2006 Aug;18;8:1108-16. doi: 10.1016/j.cell-sig.2006.02.012. Epub 2006 Feb 28.
  13. Raposo B., Dobritzsch D., Ge C., et al. Epi-Tope-Specific Antibody Response is Controlled by Immunoglobulin V(H) Polymorphisms. J. Exp. Med. 2014 Mar. 10;211;3:405-11. doi: 10.1084/jem.20130968
  14. Gromova O.A., Torshin I.YU., Lila A.M., Shavlovskaya O.A. On the Prospects of Using Undenatured Type II Collagen in the Treatment of Osteoarthritis and Other Joint Diseases. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2022;16;4:111-116 (In Russ.).
  15. Czajka A., Kania E., Genovese L., et al. Daily Oral Supplementation with Collagen Peptides Combined with Vitamins and other Bioactive Compounds Improves Skin Elasticity and has a Beneficial Effect on Joint and General Wellbeing. Nutrition Research. 2018; 57:97-108. doi: 10.1016/j.nutres.2018.06.001.
  16. Kviatkovsky S.A., Hickner R.C., Cabre H.E., et al. Collagen Peptides Supplementation Improves Function, Pain, and Physical and Mental Outcomes in Active Adults. J Int Soc Sports Nutr. 2023 Dec. 20;1:2243252. doi: 10.1080/15502783.2023.2243252. PMID: 37551682. PMCID: PMC10411303.
  17. Schön C., Knaub K., Alt W., et al. UC-II Undenatured Type II Collagen for Knee Joint Flexibility: a Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Integr Complement Med. 2022 Jun;28;6:540-548. doi: 10.1089/jicm.2021.0365. Epub 2022 Apr 4. PMID: 35377244. PMCID: PMC9232232.
  18. Devasia S., Joseph JT., Koizumi S., et al. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability. Cartilage. 2024 Dec;15;4:363-374. doi: 10.1177/19476035231221211. Epub 2024 Jan 18. PMID: 38235711. PMCID: PMC11520019.
  19. Bagchi D., Misner B., Bagchi M., et al. Effects of Orally Administered Undenatured Type II Collagen against Arthritic Inflammatory Diseases: a Mechanistic Exploration. Int J Clin Pharmacol Res. 2002;22;3-4:101-10.
  20. Alekseyeva L.I., Sharapova Ye.P. Chondroitin Sulfate in the Treatment of Osteoarthrosis. Russkiy Meditsinskiy Zhurnal = Russian Medical Journal. 2009;17;21:1448-1452 (In Russ.).
  21. Topchiy N.V. Arthrodol (Chondroitin Sulfate) – a New Remedy in the Treatment of Osteoarthrosis. Russkiy Meditsinskiy Zhurnal = Russian Medical Journal. 2013;21;6:313-318 (In Russ.).
  22. Hochberg M., Chevalier X., Henrotin Y., et al. Symptom and Structure Modification in Osteoarthritis with Pharmaceutical-Grade Chondroitin Sulfate: What’s the Evidence? Curr Med Res Opin. 2013 Mar;29;3:259-67. doi: 10.1185/03007995.2012.753430. Epub 2013 Jan 31. PMID: 23186102.
  23. Hochberg MC., Martel-Pelletier J., Monfort J., et al. MOVES Investigation Group. Combined Chondroitin Sulfate and Glucosamine for Painful Knee Osteoarthritis: a Multicentre, Randomised, Double-Blind, Non-Inferiority Trial Versus Celecoxib. Ann Rheum Dis. 2016 Jan;75;1:37-44. doi: 10.1136/annrheumdis-2014-206792. Epub 2015 Jan 14. PMID: 25589511. PMCID: PMC4717399.
  24. Berrie C. Chondroitin Sulfate is Similar to Celecoxib in Improving Pain and Function in Knee Osteoarthritis. Dnevnik Kazanskoy Meditsinskoy Shkoly = Diary of the Kazan Medical School. 2017;2:148-149 (In Russ.).
  25. Fransen M., Agaliotis M., Nairn L., et al. LEGS Study Collaborative Group. Glucosamine and Chondroitin for Knee Osteoarthritis: a Double-Blind Randomised Placebo-Controlled Clinical Trial Evaluating Single and Combination Regimens. Ann Rheum Dis. 2015 May;74;5:851-8. doi: 10.1136/annrheumdis-2013-203954. Epub 2014 Jan 6. PMID: 24395557.
  26. Vasil’yeva L.V. Long-Term Therapy with Chondroitin Sulfate in Patients with Osteoarthritis with Severe Pain Syndrome. Rannyaya Diagnostika i Sovremennyye Metody Lecheniya na Etape Pervichnogo Zvena Zdravookhraneniya = Early Diagnostics and Modern Methods of Treatment at the Primary Health Care Stage. 2017:21-27 (In Russ.).
  27. Yevstratova Ye.F., Vasil’yeva L.V., Nikitin A.V. Combined Treatment of Early Osteoarthritis of the Knee Joints in Patients with Comorbid Pathology. Proceedings of the 16th International Scientific and Practical Conference. North Carleston (USA), July 9-10, 2018. Akademicheskaya Nauka, Problemy i Dostizheniya = Academic Science, Problems and Achievements. 2018;1:9 (In Russ.).

Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 13.06.2025. Accepted for publication: 23.07.2025

© 2026 Scientific journal - "Clinical Bulletin of the FMBС im. A.I. Burnasyan"
Scroll to Top