A.I. Burnasyan Scientific journal FMBC

Clinical Bulletin

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №3 2022 год

Rules for submitting an article

Dear Authors,
The template contains requirements and recommendations for the structural elements of a research paper, and we hope it will help you present your research results in a clear and compelling way. Read the template before you start writing. Don’t worry about the formatting of the article: write in place of the text of the instructions. Remove any extra text, including this appeal, before submitting the manuscript for review.

The title of the article in Russian: short and precise, reflecting the main result of the study or the identified pattern, using keywords. No more than 12 words.
(prefer abstractions to specifics: for example, write “Allele XXX is associated with the development of disease YYY in the ZZZ population” instead of “Allele XXX and its association with the development of disease YYY”)

I. O. Last name1, First name Last name1, First name Last name2, First name Last name1< /sup>, first name last name3

1Department, faculty (or laboratory, subdivision)
Full official name of the organization, city, country

2Department, faculty (or laboratory, subdivision)
Full official name of the organization, city, country

3Full official name of the organization, city, country
The number of authors should not exceed 10 people.
Information about the authors should be indicated in Russian and English in accordance with the statutory documents of organizations!

Abstract (in Russian). The volume of the abstract should not exceed 1500 characters without spaces. Paragraphs are not highlighted. To determine the number of characters – select the abstract and use the command “Tools ® Statistics …”.
For original articles, a structured abstract is required, and for other types of articles (literature review, clinical case demonstration, experience exchange) – a standard text that reflects the main ideas of the article. For clinical trials, the abstract should also include details of where and when the trial was registered and the Clinical Trial Number, if available. The abstract may contain abbreviations used in the text. In the annotation, as well as in the title, commercial names of drugs and equipment should not be used.
A structured annotation should have the following sections:
Introduction (Background), reflecting the history of the issue and the importance of studying it.
Goal (Objective), reflecting the purpose of the study or the hypothesis that the authors of the article studied in their work.
Material and methods – the section should include a brief description of patient groups, treatment / examination options and which statistical analysis methods (with an indication of the program) were used.
Results (Results), describes the results obtained by the authors and shows / does not show their statistical significance. When describing the results of the study, do not limit yourself to stating facts, but provide numerical data both in relative and absolute terms.

Conclusions (Conclusions) are based on the results and reflect their significance
Never copy and paste parts of the manuscript into the abstract – retell them, striving for brevity. Remember that the abstract is that independent element of the article by which readers determine the significance of the publication for their work or even decide to purchase it. Express your thoughts simply, following the logic of the narrative, avoiding complex sentences.

Key words (in Russian and English): 5-10 words and/or phrases in the nominative case; include unambiguous terms on the topic of research in the CS and avoid too general concepts. The citation of the article depends on the correct choice of keywords.

Author Contribution:
indicate the contribution of each author to the work carried out, as a result of which the article was written

Compliance with ethical standards:
indicate the date of the ethics committee meeting and the protocol number; indicate whether all participants (for children – their parents or guardians) signed voluntary consent to participate in the study; when working with animals, indicate the compliance of the conditions of their maintenance and work with them with the standards for working with animals. Please do not include relevant information inside the main text, but put it in this paragraph.

Funding:
indicate a grant or any other source of research support, including a government assignment; in the absence of funding – “no”.

Thanks:
First name Last name (in the dative case) from the Organization for Contribution to the work (valuable criticisms, provided data, including drawings, etc.).

Example: Professor Ivan Ivanov from Ivanovo University for criticizing the author’s ideas; Petr Petrov from Petrovsky University for the opportunity to use the equipment of the laboratory such and such.

For correspondence: First name Middle name Last name
st. Lenina, d. 1, Moscow, 123456 (fill in the correct address)
8XXXXXXXXXX (please provide a mobile phone number; it is not published)
xxxxxxxxxxx@xxxxxxx.xx (please enter the email you actually use!)

Author information:
Data about each author of the article (in Russian and English):

Name (initials must be fully decoded); academic degree, title; full name of the place of work; full title of the position held; contact phone number (will not be specified when printing the article); E-mail address; ORCID (all authors must be registered with Open Researcher and Contributor ID). .

Please include this information for all authors. Be careful when specifying last names in Latin letters: this affects the identification of authors in abstract bases.

Example: Petr Petrovich Sidorov (Sidorov PP) – head of the research laboratory of the Russian National Research Medical University. N. I. Pirogova, Ph.D. n.

It should be translated into English:

  • affiliations of authors (in accordance with the statutory documents of organizations!),
  • keywords

The title of the article, abstract, funding and acknowledgments do not need to be translated (they will still change during the editing process, so you can waste your time).

Start writing your introduction here. Formulate the problem, describe the difficulties associated with it and the achievements of other researchers, describe the most promising ways to solve the problem at the moment. Do not be unfounded: quote colleagues! But avoid citing common truths for the sake of expanding the reference list of references, as well as self-citing (it should not exceed 15% of the total number of references). Make references in the form of serial numbers in square brackets – [1], [2], [3, 4], [5–7] and further in the text of the article. Highlight all links in color so you can easily check that they are all mentioned, their sequence is not broken). Then draw up lists of references in Russian and English, observing the order in which the sources are mentioned in the text. When you finish the article, check that the text mentions all the sources from the list, and all the sources mentioned in the text are included in the “Literature” and References.

State the purpose of your research or the hypothesis you are testing. Do not mention or discuss the results of the study in this section.

PATIENTS AND METHODS
The section can also be called “Materials and Methods” if this is the specifics of the study (laboratory animals, other laboratory models). The section should be written in such a way as to give readers an answer to two questions: how exactly was the study carried out and why was it carried out in this way and not otherwise? The level of detail should be such that the study can be reproduced.

Indicate the place and period of the study. Describe in detail the selection criteria for study participants (including exclusion criteria), give their main demographic characteristics (sex, age, sometimes ethnicity or race), and explain the significance of individual characteristics, if any. In the case of ethnicity or race, it is necessary to indicate how this characteristic was determined and why it matters. If we are talking about self-identification, this must be indicated.

Indicate all research objects, research methods and equipment (including the manufacturer and country of production), reagents and drugs, including generics (indicating the dose and method of administration to the body). Use international classifiers for the names of genes, biological molecules, reagents and drugs. The names of genes and polymorphisms should be italicized. The names of microorganisms must be italicized.

When describing widely known and generally accepted methods, a reference to the source with their detailed description is sufficient. Less common methods require a brief description and reference. If the method has been modified, describe the modifications in detail and explain why they were made.

Be sure to statistically process the results and indicate the statistical method you used. Describe it in such a way that any researcher, having access to the original data, can re-verify it. Explain statistical terms and symbols and decipher abbreviations. Specify the software package with which statistical processing was carried out, and its version, as well as the developer and country of development.

RESEARCH RESULTS
Put your results in text, tables and figures in a logical sequence. You must report results for all study subjects mentioned in the Patients and Methods section. Do not retell tables and figures: try to choose the most interesting, most significant data, and readers will be able to analyze the data array on their own. Refer to tables and figures as follows: (Table 1) and (Fig. 1). If there is only one table or one figure, refer to: (table) and (figure). The text of the article should contain links to all tabular and graphic material of the article. All links must be highlighted in color so that you can easily check that you have referred to all graphic materials. When placing figures in Word, their quality is distorted, and tables become more difficult to edit, so send figures and tables in separate files (as well as their names and explanations for them), following the formatting rules established in the corresponding Section of the Editorial Policy. The number of tables and figures is limited (no more than 6 for reviews, research articles and methods; no more than 10 for descriptions of clinical cases; no more than 2 for opinions).

DISCUSSION OF THE RESULTS
Compare your results with data from other researchers, explain the differences, make assumptions about the mechanisms of the patterns you have identified. Please do not claim that no one has investigated the problem before you. First, it is unlikely that absolutely no one ever will. Secondly, even if there is no exactly the same study, but there is something similar. Thirdly, if no one is addressing this problem, then maybe it is not worth it and you should reconsider its significance?

Remember that if you quote colleagues, pay attention to their work, then your colleagues will treat you the same way.

SUMMARY
Summarize the findings without copying parts of the article. Indicate whether the goal of the study was achieved, and if it failed, explain the reason. Give an opinion on how the field of study should be developed further; describe possible options for using the results obtained in further research or clinical practice; formulate new hypotheses, but clearly indicate that these are just hypotheses, and not experimentally confirmed conclusions.

The length of the article is limited: up to 20,000 characters without spaces for an article describing an original study or method, up to 10,000 characters for an article describing a clinical case and for an opinion, up to 25,000 characters without spaces for an overview. The abstract, keywords and list of references are not included in this volume.

Literature (References)
A scientific article describing an original study or method should have up to 30 citations; in an article describing a clinical case or in an opinion – up to 15; in the review – up to 50. Self-citation should not exceed 15%. The number of references for the last 5 years is not regulated, but the journal assumes that the “older” the references, the higher the probability that the subject of research is not interesting or the authors are not sufficiently knowledgeable in the field of research, and this indicates unprofessionalism. You can refer to articles, books, collections of materials, scientific and technical reports, dissertations, patents, regulatory documents, newspaper publications, entries in scientific blogs. It is forbidden to refer to materials whose authorship cannot be established (the authors can be both individual researchers and organizations), or to near-scientific Internet resources (educational materials for students, etc.). It is not recommended to refer to tutorials. The journal adopted the Sample References reference design standard. Below are examples of link formatting. If you don’t find a suitable example here, go to https://www.nlm.nih.gov/bsd/uniform_requirements .html.

The list must be issued in Russian (Literature) and English (References) languages. The names of English-language sources are the same in both, and Russian-language sources for References are transliterated using the http://translit.net service (BGN standard) or their translated names, if any.

    1. Skoroglyadov A. V., But-Gusaim A. B., Sirotin I. V., Pimenov A. A., Krapivin A. A., Stepanov N. V. et al. Experience in organizing the provision of high-tech medical care in traumatology and orthopedics. Bulletin of the RSMU. 2013; (1): 28-30. Journal article. Indicate 6 authors, then use the abbreviation “et al.” or “et al.” The name of the journal is indicated in its entirety or the accepted abbreviation is used (check the information on the journal’s website or Index Medicus). Mandatory indication of the year of publication, volume (and/or number), page range.
    2. Liga AB, Ukhina TV, Rzheznikov VM, Shimanovsky NL Investigation of the proliferative activity of rat skin fibroblasts under the influence of glucocorticoids and gestagens. Expert. and wedge. pharmacol. 2008; 71 (5): 44-7.
    3. Liga AB, Ukhina TV, Rzheznikov VM, Shimanovskiy NL. Issledovanie proliferativnoi aktivnosti fibroblastov kozhi krys pri vozdeistvii glyukokortikoidov i gestagenov. i klin. farmakol. 2008; 71(5):44-7. Russian. An example of transliteration of a Russian-language link for References. Do not include a diacritic (‘) in last names, which means a soft sign, but leave it in the title of the article.
    4. Halpern SD, Ubel PA, Caplan AL. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002; 347(4): 284-7. PubMed PMID: 12140307. Electronic ID is optional.
    5. Trachtenberg F, Maserejian NN, Soncini JA, Hayes C, Tavares M. Does fluoride in compomers prevent future caries in children? J Dent Res. 2009; 88(3): 276-9. PubMed PMID: 19329464. ClinicalTrials.gov registration number: NCT00065988. Indication of the registration number of the clinical trial is optional.
    6. Abood S. Quality improvement initiative in nursing homes: the ANA acts in an advisory role. Am J Nurs [Internet]. 2002 Jun [cited 2002 Aug 12]; 102 (6): [about 1 p.]. Available from: http://www.nursingworld.org/AJN/2002/june/Wawatch.htmArticle</ a> Article in an electronic journal.
    7. Simonova AV Phenotype of blood lymphocytes in human inflammatory diseases. M.: Publishing house “INTO”; 2001. 228 p. Book with author.
    8. V. N. Serova, G. T. Sukhikh, editors. Clinical guidelines. Obstetrics and gynecology. 4th ed., revised. and additional Moscow: GEOTAR-Media; 2014. 1024 p. A book that has no authors but editors.
    9. Gilstrap LC 3rd, Cunningham FG, VanDorsten JP, editors. Operative obstetrics. 2nd ed. New York: McGraw-Hill; 2002. A book that has no authors, but has editors.
    10. Koroleva S. V., Kovalev V. A. The choice of the method of surgical intervention in Peyronie’s disease. In the book: Lopatkin N. A., Martova A. G., editors. Selected lectures on urology. M., 2008. S. 473-81. A chapter in a book.
    11. Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumors. In: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. New York: McGraw-Hill; 2002.p. 93–113. A chapter in a book.
    12. Aidumova O. Yu. Markers of cardiorenal syndrome and prognosis in patients with chronic heart failure with reduced ejection fraction. In the collection: Materials of the X International (XIX All-Russian) Pirogov Scientific Medical Conference of Students and Young Scientists; March 19, 2015; Moscow. Vestnik RSMU 2015; (2): 110. Report in the conference proceedings.
    13. Christensen S, Oppacher F. An analysis of Koza’s computational effort statistic for genetic programming. In: Foster JA, Lutton E, Miller J, Ryan C, Tettamanzi AG, editors. genetic programming. EuroGP 2002: Proceedings of the 5th European Conference on Genetic Programming; 2002 Apr 3-5; Kinsdale, Ireland. Berlin: Springer; 2002.p. 182-91. Report in the collection of conference materials.
    14. Lebedev Yu. B., Zvyagin I. V., Britanova O. V., Minervina A. A., Komech E. A., Nazarov V. I. et al. lymphoblasts. Interim report on PNI. M.: Institute of Bioorganic Chemistry. Academicians M. M. Shemyakin and Yu. A. Ovchinnikov RAS; June 2015 Agreement with the Ministry of Education and Science of the Russian Federation No. 14.604.21.0118. State registration number VNTIC: 114112440009. Scientific and technical report.
    15. Russell ML, Goth-Goldstein R, Apte MG, Fisk WJ. Method for measuring the size distribution of airborne Rhinovirus. Berkeley (CA): Lawrence Berkeley National Laboratory, Environmental Energy Technologies Division; 2002 Jan. Report No.: LBNL49574. Contract No.: DEAC0376SF00098. Sponsored by the Department of Energy. Report in the collection of conference materials.
    16. Lukoyanova TV Substantiation and evaluation of the effectiveness of etidronic acid for the prevention and complex treatment of inflammatory diseases of the oral cavity [thesis]. M.: 2011. Dissertation.
    17. Borkowski MM. Infant sleep and feeding: a telephone survey of Hispanic Americans [dissertation]. Mount Pleasant (MI): Central Michigan University; 2002. Dissertation.
    18. D. D. Abramov, D. Yu. Trofimov, D. V. Rebrikov, authors; ZAO Scientific and Production Company DNA-Technology, patent holder. A method for determining the presence of a “hot start” in the polymerase chain reaction. Patent of the Russian Federation No. 2346986. 20.02.2009. Patent
    19. Pagedas AC, inventor; Ancel Surgical R&D Inc., assignee. Flexible endoscopic grasping and cutting device and positioning tool assembly. United States patent US 20020103498. 2002 Aug 1. Patent
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