A.I. BURNASYAN FMBC CLINICAL BULLETIN

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №1, 2026

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A.I. Burnasyan  FMBC clinical bulletin. 2025 № 4

A.A. Zavialov., A.B. Kodirova, V.I. Arkhipova, M.Sh. Zugumova, N.G. Stepanyants

Modern Diagnostics and Treatment Strategy for Extramammary Pedjet’s Disease:
Evidence-Based Medicine Data

International Office, State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russiа

Contact person: Kodirova Аdiba Bakhromovna: kodirova-adiba01@mail.ru

 

Abstract
Extramammary Paget’s disease (EPMD) is a rare form of adenocarcinoma affecting the anogenital area and perineum. Low prevalence, nonspecific clinical picture and absence of pathognomonic symptoms make primary diagnosis difficult. Difficulties in diagnosis determine the importance of timely skin biopsy, the most informative method of disease verification. The number of standard methods of treatment of this pathology is limited, which increases the relevance of the application of approaches that have proven to be effective in tumors of other localizations, taking into account their molecular and biological characteristics.

EMBP is characterized by a high probability of developing local recurrences and distant metastases, which determines the need for radical surgical intervention as the main method of therapy. Early diagnosis and a multidisciplinary approach are critical for improving outcomes.

Materials and methods: the search for sources of information was conducted in PubMed and Google Scholar. The literature review covered a period of 15 years. When systematizing the material, preference was given to scientific papers published between 2019 and 2025.

The paper discusses the clinical features of the disease, methods of differential diagnosis, and current approaches to histological and immunohistochemical verification. It also provides a comparative assessment of the effectiveness of surgical, radiation, and medical treatment methods. Special attention is paid to the problem of high relapse rates, which determines the need to optimize treatment strategies and implement a personalized approach.

Keywords: extramammary Paget’s disease, anogenital adenocarcinoma, immunohistochemistry, Moh’s surgery, photodynamic therapy

For citation: Zavialov AA, Kodirova AB, Arkhipova VI, Zugumova MSh, Stepanyants NG. Modern Diagnostics and Treatment Strategy for Extramammary Pedjet’s Disease: Evidence-Based Medicine Data. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2025.4:53-58. (In Russian) DOI: 10.33266/2782-6430-2025-4-53-58

 

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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 12.08.2025. Accepted for publication: 25.09.2025

© 2026 Scientific journal - "Clinical Bulletin of the FMBС im. A.I. Burnasyan"
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