A.I. BURNASYAN FMBC CLINICAL BULLETIN

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №1, 2026

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A.I. Burnasyan  FMBC clinical bulletin. 2026 № 1

A.E. Krasnov1, Yu.D. Udalov1, M.R. Gataullin2, G.A. Gadelshina3, E.N. Mingazova4,5,6

Chronic Cardiovascular Pathology as a Risk Factor for Death
in Patients with Coronavirus Infection

¹International Office, State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russiа
²State Autonomous Healthcare Institution “Republican Clinical Hospital”
3Kazan National Research Technological University
4N.A. Semashko National Research Institute of Public Health
5Kazan State Medical University
6Russian Medical Academy of Continuous Professional Education

Contact person: Krasnov Aleksey Evgenievich: aekmu@mail.ru

 

Abstract
The aim of the study was to assess the impact of age and chronic cardiovascular diseases on in-hospital mortality in patients with coronavirus infection. A retrospective analysis of 16,854 medical records of patients with confirmed COVID-19 admitted to a specialized hospital was conducted. Based on medical information system data, two groups were identified: survivors and deceased. Statistical analysis included nonparametric tests and calculation of odds ratios (OR) with a 95 % confidence interval. Deceased patients were significantly older than survivors. (median 72 vs. 62 years; p < 0.001). The presence of arterial hypertension, coronary artery disease, chronic heart failure, atrial fibrillation/flutter, and chronic cardiac conduction disorders was associated with a significantly increased risk of death (OR from ≈2.6 to ≈3.9). These results highlight the key role of age and cardiovascular comorbidity in shaping the risk of death in COVID-19 and substantiate the need for targeted risk stratification, enhanced monitoring, and optimized treatment for this patient population.

Keywords: mortality, coronavirus infection;,in-hospital mortality, cardiovascular comorbidity, risk factors

For citation: Krasnov AE, Udalov YuD, Gataullin MR, Gadelshina GA, Mingazova EN. Chronic Cardiovascular Pathology as a Risk Factor for Death in Patients with Coronavirus Infectiona. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2026.1:76-84. (In Russian) DOI: 10.33266/2782-6430-2026-1-76-84

 

REFERENCES

  1. Pranata R., Lim M.A., Huang I., Raharjo S.B., Lukito A.A. Hypertension is Associated with Increased Mortality and Severity of Disease in COVID-19 Pneumonia: a Systematic Review, Meta-Analysis and Meta-Regression. Journal of the Renin-Angiotensin-Aldosterone System. 2020;21;2:1470320320926899. Doi: 10.1177/1470320320926899.
  2. Parohan M., Yaghoubi S., Seraji A., Javanbakht M. H., Sarraf P., Djalali M. Risk Factors for Mortality in Patients with Coronavirus Disease 2019 (COVID-19) Infection: a Systematic Review and Meta-Analysis of Observational Studies. The Aging Male. 2020;23;5:1416–1424. Doi: 10.1080/13685538.2020.1774748.
  3. Al-Qudimat A.R., Ameen A., Sabir D.M., et al. The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: an Update with Meta-Analysis. Journal of Epidemiology and Global Health. 2023;13:495–503. Doi: 10.1007/s44197-023-00130-3.
  4. Gu T., Chu Q., Yu Z., Fa B., Li A., Xu L., Wu R., He Y. History of Coronary Heart Disease Increased the Mortality rate of Patients with COVID-19: a Nested Case-Control Study. BMJ Open. 2020;10;9:e038976. Doi: 10.1136/bmjopen-2020-038976.
  5. Liang C., Zhang W., Li S., Qin G. Coronary Heart Disease and COVID-19: a Meta-Analysis. Med. Clin. (Barc). 2021;156;11:547–554. Doi: 10.1016/j.medcli.2020.12.017.
  6. Szarpak L., Mierzejewska M., Jurek J., et al. Effect of Coronary Artery Disease on COVID-19 – Prognosis and Risk Assessment: a Systematic Review and Meta-Analysis. Biology. 2022;11;2:221. Doi: 10.3390/biology11020221.
  7. Wang S., Zhu R., Zhang C., et al. Effects of the Pre-Existing Coronary Heart Disease on the Prognosis of COVID-19 Patients: a Systematic Review and Meta-Analysis. PLoS One. 2023;18;10:e0292021. Doi: 10.1371/journal.pone.0292021.
  8. Yonas E., Alwi I., Pranata R., Huang I., Lim M. A., Gutierrez E. J., Siswanto B.B., Virani S. S., Yamin M. Effect of Heart Failure on the Outcome of COVID-19 – a Meta Analysis and Systematic Review. American Journal of Emergency Medicine. 2021;46:204–211. Doi: 10.1016/j.ajem.2020.07.009.
  9. Arutyunov G.P., Tarlovskaya E.I., Arutyunov A.G., Lopatin Y.M. Activ Investigators. Impact of Heart Failure on All-Cause Mortality in COVID-19: Findings from the Eurasian International Registry. ESC Heart Failure. 2023. Vol.10, No.2. P. 1013–1024. Doi: 10.1002/ehf2.14243.
  10. Cianci R., Caldarelli M., Rio P., Pignataro G., Sacco Fernandez M., Ocarino F., Della Polla D.A., Franceschi F., Gasbarrini A., Gambassi G., et al. Outcomes of Patients with Heart Failure Hospitalized for COVID-19 – a Study in a Tertiary Italian Center. Diseases. 2024;12;12:337. Doi: 10.3390/diseases12120337.
  11. Li Z., Shao W., Zhang J., Ma J., Huang S., Yu P., Zhu W., Liu X. Prevalence of Atrial Fibrillation and Associated Mortality among Hospitalized Patients with COVID-19: a Systematic Review and Meta-Analysis. Frontiers in Cardiovascular Medicine. 2021;8:720129. Doi: 10.3389/fcvm.2021.720129.
  12. Romiti G.F., Corica B., Lip G.Y.H., Proietti M. Prevalence and Impact of Atrial Fibrillation in Hospitalized Patients with COVID-19: a Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2021;10;11:2490. Doi: 10.3390/jcm10112490.
  13. Yang H., Liang X., Xu J., Hou H., Wang Y. Meta-Analysis of Atrial Fibrillation in Patients with COVID-19. American Journal of Cardiology. 2021;144:152–156. Doi: 10.1016/j.amjcard.2021.01.010.
  14. De Carvalho H., Letrou S., Mathian A., et al. Electrocardiographic Abnormalities in COVID-19 Patients Visiting the Emergency Department: a Multicenter Retrospective Study. BMC Emergency Medicine. 2021;21:112. Doi: 10.1186/s12873-021-00539-8.
  15. De Vita A., Ravenna S.E., Covino M., et al. Electrocardiographic Findings and Clinical Outcome in Patients with COVID-19 or Other Acute Infectious Respiratory Diseases. Journal of Clinical Medicine. 2020;9;11:3647. Doi: 10.3390/jcm9113647.
  16. Zuin M., Rigatelli G., Zuliani G., et al. Left Bundle Branch Block and Mortality in COVID-19 Patients. American Journal of Cardiology. 2021;153:149–150. Doi: 10.1016/j.amjcard.2021.05.031.
  17. Zuin M., Rigatelli G., Bilato C. Mortality Risk in COVID-19 Patients with Right Bundle Branch Block. Revista Española de Cardiología (English Edition). 2021;74;12:1122–1124. Doi: 10.1016/j.rec.2021.06.014.
  18. Salim Bahrami S.A.R., Alshargabi B., Monajem M.M., et al. Relationship of Right and Left Bundle Branch Blocks to Mortality in COVID-19 Patients Hospitalized in the Intensive Care Unit: a Descriptive-Analytical Retrospective Study. Mædica – a Journal of Clinical Medicine. 2024;19;4:726–730. Doi: 10.26574/maedica.2024.19.4.726.
  19. Chevrot G., Hauguel-Moreau M., Pépin M., et al. Electrocardiogram abnormalities and prognosis in COVID-19. Frontiers in Cardiovascular Medicine. 2022;9:993479. Doi: 10.3389/fcvm.2022.993479.

Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 29.11.2025. Accepted for publication: 27.12.2025

© 2026 Scientific journal - "Clinical Bulletin of the FMBС im. A.I. Burnasyan"
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