A.I. BURNASYAN FMBC CLINICAL BULLETIN

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №2 2025 год

A.I. Burnasyan  FMBC clinical bulletin. 2022 № 4

A.S. Samoylov1, A.V. Zholinskiy2, N.V. Rylova1, I.V. Bolshakov1

Diagnosis of Autonomic Dysfunction Syndrome in Young Atheletes

1Burnasyan State Research Center – Federal Medical Biophysical Center of Federal Medical Biological Agency
2Federal scientific and clinical center for sports medicine and rehabilitation of the FMBA of Russia, Moscow

Contact person: Rylova Nataliya Victorovna: rilovanv@mail.ru

Abstract
Purpose: A review of the most common and effective from the point of view of evidence-based medicine methods for diagnosing autonomic dysfunction syndrome in young athletes.
Material and methods: The data of domestic and foreign literature on the diagnosis of autonomic dysfunction syndrome were analyzed. The search was carried out using electronic databases MEDLINE, Embase, Scopus, Web of Science, eLIBRARY and Google Academy for the period from 2017 to 2022. For the search, we used keywords and their combinations: “vegetative dysfunction syndrome”, “athletes”, “diagnostics”, “functional tests”. A total of 28 sources analyzed
Results: The autonomic dysfunction syndrome (ADS) is characterized by a significant polymorphism of clinical manifestations and is characterized by functional disorders of the activity of the cardiovascular, endocrine and other systems of the body. Diagnosis of this condition is associated with great difficulties associated with the nonspecificity of symptoms, their bright emotional color and the absence of morphological changes in organs. The frequent manifestation of ADS in childhood and adolescence, the proven relationship of symptoms with exercise and mental stress, determines the importance of early and effective diagnosis of this syndrome in young athletes. The key research methods for suspected autonomic dysfunction syndrome include taking anamnesis using special questionnaires and scales and conducting functional tests with registration of the parameters of the cardiovascular system (heart rate, blood pressure, HRV). The most common and informative functional tests: deep controlled breathing test, orthostatic test (active and passive), Valsalva test. Promising methods for diagnosing ADS include accelerometric tremorography and the study of baroreflex sensitivity. Also, for a deeper examination of a young athlete, it is recommended to use laboratory diagnostic methods to identify violations of the endocrine system, detect changes in lipid and carbohydrate metabolism, etc. Conclusions: At the moment, further research is needed to study the autonomic dysfunction syndrome and methods for its diagnosis.

Keywords: autonomic dysfunction syndrome, athletes, diagnostics, functional tests

For citation:  Samoylov AS, Zholinskiy AV, Rylova NV, Bolshakov IV. Diagnosis of Autonomic Dysfunction Syndrome in Young Atheletes. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2022.4:5-11. (In Russian) DOI: 10.33266/2782-6430-2022-4-5-11


REFERENCES

  1. Mulkey S.B., du Plessis A.J. Autonomic Nervous System Development and its Impact on Neuropsychiatric Outcome. Pediatr Res. 2019;85;2:120-126. DOI: 10.1038/s41390-018-0155-0.
  2. Sharapov A.N., Dogadkina S.B., Rubleva L.V., Kmit G.V., Bezobrazova V.N. Functional State of the Cardiovascular System in 13-Year-Old Adolescents with Different Types of Autonomic Nervous Regulation. Fiziologiya Cheloveka = Human Physiology. 2017;43;2:31–42 (In Russ.). DOI: 10.1134/S0362119717020141.
  3. Shashel V.A., Podporina L.A., Panesh G.B., Ponomarenko D.S., Dobryakov P.Ye. Age-Related Aspects of Vegetative Status in Children with Vegetative Dystonia Syndrome. Kubanskiy Nauchnyy Meditsinskiy Vestnik = Kuban Scientific Medical Bulletin. 2017;24;4:169-172 (In Russ.). DOI: 10.25207/1608-6228-2017-24-4-169-172.
  4. Fiuza-Luces C., Santos-Lozano A., Joyner M., Carrera-Bastos P., Picazo O., Zugaza J.L., Izquierdo M., Ruilope L.M., Lucia A. Exercise Benefits in Cardiovascular Disease: Beyond Attenuation of Traditional Risk Factors. Nat. Rev. Cardiol. 2018;15;12:731-743. DOI: 10.1038/s41569-018-0065-1.
  5. Tvorogova T.M., Zakharova I.N. Pshenichnikova I.I. Autonomic Dysfunctional and Cardiovascular Disease in Children. Meditsinskiy Sovet = Medical Council. 2017;19:208-212 (In Russ.). DOI: 10.21518/2079-701X-2017-19-208-212.
  6. Chutko L.S., Surushkina S.Yu., Yakovenko Ye.A., Kornishina T.L. Syndrome of Vegetative Dysfunction in Children and Adolescents. Clinical and Psychophysiological Manifestations and Therapy (review). Praktika Pediatra = Paediatrician Practice. 2019;3:17-21 (In Russ.).
  7. Chutko L.S., Kornishina T.L., Surushkina S.YU., Yakovenko Ye.A., Anisimova T.I., Volov M.B. Syndrome of Autonomic Dysfunction in Children and Adolescents. Zhurnal Nevrologii i Psikhiatrii Im. S.S. Korsakova = The Korsakov’s Journal of Neurology and Psychiatry. 2018;1:43-49 (In Russ.). DOI: 10.17116/jnevro20181181143-49.
  8. Kukhtevich I.I., Aleshina N.I. Vegetative Dystonia Syndrome as a Somatoform Disorder. Saratovskiy Nauchno-Meditsinskiy Zhurnal = Saratov Journal of Medical Scientific Research. 2019;15;1:159-162 (In Russ.).
  9. Vetsler M.V., Cherkasova V.G., Kovalev M.A., Muravyev S.V., Chaynikov P.N. Affective Disorders and Dyssomnias in University Students Depending on Sports Activities. Sibirskoye Meditsinskoye Obozreniye = Medical Review. 2019;1:63-74 (In Russ.). DOI: 10.20333/2500136-2019-1-63-74.
  10. Kuchma V.R., Sukhareva L.M., Nadezhdin D.S., Sakharov V.G., Goncharova G.A. The Study of the Psychophysiological and Psychosocial Characteristics of 9—11th Grade Students of Secondary School. Rossiyskiy Pediatricheskiy Zhurnal= Russian Pediatric Journal. 2017;20;6:346-353. (In Russ.). DOI: 10.18821/1560-9561-2017-20-6-346-353.
  11. Edwards T., Spiteri T., Piggott B., Bonhotal J. Monitoring and Managing Fatigue in Basketball. Sports (Basel). 2018;6;1:19. DOI: 10.3390/sports6010019.
  12. Bellavere F, Ragazzi E, Chilelli NC, Lapolla A, Bax G. Autonomic Testing: Which Value for Each Cardiovascular Test? An Observational Study. Acta Diabetol. 2019 Jan;56(1):39-43. DOI: 10.1007/s00592-018-1215-y. PMID: 30159748.
  13. Illigens B.M.W., Gibbons C.H. Autonomic Testing, Methods and Techniques. Handb Clin. Neurol. 2019;160:419-433. DOI: 10.1016/B978-0-444-64032-1.00028-X.
  14. Shaffer F., Ginsberg J.P. An Overview of Heart Rate Variability Metrics and Norms. Front. Public. Health. 2017;5:258. DOI: 10.3389/fpubh.2017.00258.
  15. Spitsin A.P. Peculiarities of Heart Rate Structure in Young Persons Depending on the Dominant Type of the Vergetative Nervous System. Kurskiy Nauchno-Prakticheskiy Vestnik Chelovek i Yego Zdorovye= Humans and Their Health. 2017;3:113-117 (In Russ.). DOI: 10.21626/vestnik/2017-3/19.
  16. Ziemssen T., Siepmann T. The Investigation of the Cardiovascular and Sudomotor Autonomic Nervous System-A Review. Front. Neurol. 2019;10:53. DOI: 10.3389/fneur.2019.00053.
  17. Luchnikova O.V. Estimation of Load Samples by Indicators of Heart Rate Variability for Military Services. Izvestiya Rossiyskoy Voyenno-Meditsinskoy Akademii = Russian Military Medical Academy Reports. 2020;39;S3-5:70-73 (In Russ.).
  18. Magkas N., Tsioufis C., Thomopoulos C., Dilaveris P., Georgiopoulos G., Sanidas E., Papademetriou V., Tousoulis D. Orthostatic Hypotension: From Pathophysiology to Clinical Applications and Therapeutic Considerations. J. Clin. Hypertens. (Greenwich). 2019;21;5:546-554. DOI: 10.1111/jch.13521.
  19. Goldstein D.S., Cheshire W.P. Jr. Beat-to-Beat Blood Pressure and Heart Rate Responses to the Valsalva Maneuver. Clin. Auton. Res. 2017;27;6:361-367. DOI: 10.1007/s10286-017-0474-y.
  20. Mashin V.V., Belova L.A., Ayzatullin I.F., Pavlova V.A., Slasten YE.V., Abramova V.V., Belov D.V. Evaluation of the Efficacy and Safety of Application of the Drug Cortexin in the Complex Rehabilitation of Verticalization in Patients with Ischemic Stroke in the Acute Period. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova = The Korsakov’s Journal of Neurology and Psychiatry. 2019;119;9:62-67 (In Russ.). DOI: 10.17116/jnevro201911909162.
  21. Goldberger J.J., Arora R., Buckley U., Shivkumar K. Autonomic Nervous System Dysfunction: JACC Focus Seminar // J. Am. Coll. Cardiol. 2019;73;10:1189-1206. DOI: 10.1016/j.jacc.2018.12.064.
  22. Pevzner A.V., Zyuzina N.Ye., KHeymets G.I., Rogoza A.N. Differential Diagnostics of Vasovagal Fainting, Orthostatic Hypotension and Baroreflex Failure in a Patient With Syncope. Kardiologiia = Kardiologiya. 2018;58;5:91-96 (In Russ.). DOI: 10.18087/cardio.2018.5.10126.
  23. Quispe R.C., Novak P. Auxiliary Tests of Autonomic Functions // J. Clin. Neurophysiol. 2021;38;4:262-273. DOI10.1097/WNP0000000000000626.
  24. Aleksandrova Ye.A., Borodacheva I.V., Belyakov K.M., Gustov A.V., Parshina Ye.V., Suslov A.G. Accelerometric Tremorography Opportunities for Monitoring Vegetative-vascular Dystonia Therapy Effectiveness. Meditsinskiy Almanakh = Medical Almanac. 2018;5;56:72-76 (In Russ.). DOI: 10.21145/2499-9954-2018-5-72-76.
  25. Milashechkina Ye.A., Dzhandarova T.I. Functional Status of the Hypothalamic-Pituitary-Adrenocortical and Hypothalamic-Pituitary-Gonadal Systems in Females with Vascular Dystonia. Chelovek. Sport. Meditsina = Human. Sport. Medicine. 2020;20;1:21-28 (In Russ.). DOI: 10.14529/hsm200103.
  26. Neudakhin Ye.V. Substantiation of Energotropic Therapy of Vegetative Disorders in Children. RMZH (Russkiy Meditsinskiy Zhurnal). 2018;2;2:107–112 (In Russ.).
  27. Buryak V.N. Features of Functional Activity of the Hypophysis-thyroid System in Children with a Vegeto-vascular Dysfunction by a Hypotensive Type Aftering a Perinatal Desease of the Central Nervous System. Nevrologiya Sibiri. 2020;1;7:47-50 (In Russ.).
  28. Shcherbakova M.Yu., Artykova T.K. Lipid Peroxidation in Children with Vegetative Dysfunction in Various Climatic and Geographical Conditions. Doktor.Ru = Doctor.Ru. 2018;5;149:42–46 (In Russ.). DOI: 10.31550/1727-2378-2018-149-5-42-46.

Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 01.08.2022. Accepted for publication: 28.08.2022

Scroll to Top