A.I. Burnasyan  FMBC clinical bulletin. 2023 № 3

O.V.Karpova, E.V. Bril’

Aspects of the Use of Antithrombotic Therapy in Vascular Neurology

International Office, State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russiа

Contact person: Karpova Olga Valentinovna: okarpova@fmbcfmba.ru

Abstract
The development of Acute Cerebrovascular Events – ACV is one of the main causes of mortality and disability. Currently, in developed countries, due to the development of new technologies and improvement of medical care and prevention, there is a tendency to decrease the mortality and morbidity of cerebrovascular disease (CVD). Timely and adequate use of antithrombotic therapy in patients in this category for primary and secondary prevention of ACV is an extremely important aspect of management and reliably reduces the risks of recurrent cerebrovascular accidents, increases survival and contributes to a more favorable prognosis for the recovery of impaired functions and quality of life in the long term.

Keywords: stroke, ACV, cerebral venous thrombosis, approach to antithrombotic therapy

For citation: Karpova OV, Bril’ EV. Aspects of the Use of Antithrombotic Therapy in Vascular Neurology. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2023.3:21-26. (In Russian) DOI: 10.33266/2782-6430-2023-3-21-26

 

REFERENCES

1. The top 10 Causes of Death // WHO. Archived Fromtheoriginalon 2013-12-02.

2. Мачинский П.А., Плотникова Н.А., Ульянкин В.Е., Кемайкин С.П., Рыбаков А.Г. Сравнительная характеристика показателей смертности и летальности от ишемического и геморрагического инсультов в России // Известия высших учебных заведений. Поволжский регион. Медицинские науки. 2019. № 3. С. 101-118.

Machinskiy P.A., Plotnikova N.A., Ulyankin V.E., Kemaykin S.P., Rybakov A.G. Comparative Characteristics of the Indicators of Mortality and Letality From Ischemic and Hemorrhagic Insult in Russia. Izvestiya Vysshikh Uchebnykh Zavedeniy. Povolzhskiy Region. Meditsinskiye Nauki = University Proceedings. Volga Region. Medical Sciences. 2019;3:101-118 (In Russ.).

3. Дамулин И.В., Андреев Д.А., Салпагарова З.К. Кардиоэмболический инсульт // Неврология, нейропсихиатрия, психосоматика. 2015. № 1. С. 80-86.

Damulin I.V., Andreyev D.A., Salpagarova Z.K. Cardioembolic stroke. Nevrologiya, Neyropsikhiatriya, Psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2015;1:80-86 (In Russ.).

4. Парфенов В.А., Вербицкая С.В. Факторы риска и патогенетические подтипы ишемического инсульта // Атеротромбоз. 2012. № 1. С. 16-25.

Parfenov V.A., Verbitskaya S.V. Risk Factors and Pathogenetic Subtypes of Ischemic Stroke. Aterotromboz = Atherothrombosis. 2012;1:16-25 (In Russ.).

5. Ишемический инсульт и транзиторная ишемическая атака у взрослых: Клинические рекомендации. М., 2021.

Ishemicheskiy Insult i Tranzitornaya Ishemicheskaya Ataka u Vzroslykh = Ischemic Stroke and Transient Ischemic Attack in Adults: Clinical Guidelines. Moscow Publ., 2021 (In Russ.).

6. Полипрагмазия в клинической практике: проблема и решения / Под ред. Сычева Д.А. СПб.: Профессия, 2018. 272 с.

Polipragmaziya v Klinicheskoy Praktike: Problema i Resheniya = Polypharmacy in Clinical Practice: Problem and Solutions. Ed. Sychev D.A. St. Petersburg Publ., 2018. 272 p. (In Russ.).

7. Савелло А.В., Вознюк И.А., Свистов Д.В. и др. Внутрисосудистое лечение ишемического инсульта в острейшем периоде: Клинические рекомендации. СПб, 2015.

Savello A.V., Voznyuk I.A., Svistov D.V., et al. Vnutrisosudistoye Lecheniye Ishemicheskogo Insulta v Ostreyshem Periode = Intravascular Treatment of Ischemic Stroke in the Acute Period. Clinical Guidelines. St. Petersburg Publ., 2015 (In Russ.).

8. Johnston S.C., Rothwell P.M., Nguyen-Huynh M.N., et al. Validation and Refinement of Scores to Predict Very Early Stroke Risk after Transient Ischaemic Attack // Lancet. 2007. V.369, No. 9558. P. 283-292.

9. Merwick A., Albers G.W., Amarenco P., Arsava E.M., Ay H., Calvet D., et al. Addition of Brain and Carotid Imaging to the ABCD2 Score to Identify Patients at Early Risk of Stroke after Transient Ischaemic Attack: a Multicentre Observational Study // Lancet Neurol. 2010. No. 9. P. 1060–1069.

10. Cairns J.A. ACP Journal Club. CHA2DS2-VASc Had Better Discrimination than CHADS2 for Predicting Risk for Thromboembolism in Atrial Fibrillation // Ann. Intern. Med. 2011. V.154, No. 10. P. JC5-13.

11. Lip G.Y., Nieuwlaat R., Pisters R., Lane D.A., Crijns H.J. Refining Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Using a Novel Risk Factor-Based Approach: the Euro Heart Survey on atrial Fibrillation // Chest. 2010. V.137, No. 2. P. 263-272.

12. Диагностика и лечение фибрилляции предсердий: Клинические рекомендации. 2017.

Diagnostika i Lecheniye Fibrillyatsii Predserdiy = Diagnosis and Treatment of Atrial Fibrillation. Clinical Guidelines. 2017 (In Russ.).

13. Kirchhof P., Benussi S., Kotecha D., Ahlsson A., Atar D., Casadei B., Castella M., Diener H.C., Heidbuchel H., Hendriks J., Hindricks G., Manolis A.S., Oldgren J., Popescu B.A., Schotten U., Van Putte B., Vardas P., ESC Scientific Document Group. 2016 ESC Guidelines for the Management of Atrial Fibrillation Developed in Collaboration with EACTS // Eur. Heart J. 2016. V.37, No. 38. P. 2893–2962. doi: 10.1093/eurheartj/ehw210.

14. January C.T., Wann L.S., Alpert J.S., Calkins H., Cigarroa J.E., Cleveland J.C.Jr., Conti J.B., Ellinor P.T., Ezekowitz M.D., Field M.E., Murray K.T., Sacco R.L., Stevenson W.G., Tchou P.J., Tracy C.M., Yancy C.W., ACC/AHA Task Force Members. 2014 AHA/ACC/HRS Guideline for the Management of Patients with Atrial Fibrillation: Executive Summary: a Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society // Circulation. 2014. V.130, No. 23. P. 2071-2104. doi: 10.1161/CIR.0000000000000040.

15. Ишемический инсульт и транзиторная ишемическая атака у взрослых: Клинические рекомендации. 2021.

Ishemicheskiy Insult i Tranzitornaya Ishemicheskaya Ataka u Vzroslykh = Ischemic Stroke and Transient Ischemic Attack in Adults. Clinical Guidelines. 2021 (In Russ.).

16. European Heart Rhythm Association, European Association for Cardio-Thoracic Surgery, Camm A.J., Kirchhof P., Lip G.Y., Schotten U., Savelieva I., Ernst S., Van Gelder I.C., Al-Attar N., Hindricks G., Prendergast B., Heidbuchel H., Alfieri O., Angelini A., Atar D., Colonna P., De Caterina R., De Sutter J., Goette A., Gorenek B., Heldal M., Hohloser S.H., Kolh P., Le Heuzey J.Y., Ponikowski P., Rutten F.H. Guidelines for the Management of Atrial Fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC) // Eur. Heart. J. 2010. V.31, No. 19. P. 2369-2429. doi: 10.1093/eurheartj/ehq278.

17. Панченко Е.П., Кропачевой Е.С. Рекомендации по антитромботической терапии у больных со стабильными проявлениями атеротромбоза. // Атеротромбоз. 2009. № 1. С. 38–54.

Panchenko E.P., Kropachevoy E.S. Rekomendatsii po Antitromboticheskoy Terapii u Bolnykh so Stabilnymi Proyavleniyami Aterotromboza = Recommendations for Antithrombotic Therapy IN Patients with Stable Manifestations of Atherotrombosis. Aterotromboz = Atherothrombosis. 209;1:38-54 (In Russ.).

18. Геморрагический инсульт: Клинические рекомендации. 2021.

Gemorragicheskiy Insult = Hemorrhagic Stroke. Clinical Guidelines. 2021 (In Russ.).

19. Witt D.M. What to do after The Bleed: Resuming Anticoagulation after Major Bleeding // Hematology Am. Soc. Hematol. Educ. Program. 2016. V.2016, No. 1. P. 620-624.

20. Colantino A, Jaffer AK, Brotman DJ. Resuming anticoagulation after hemorrhage: A practical approach. Cleve Clin J Med. 2015 Apr;82(4):245-56. doi:10.3949/ccjm.82a.14047. Review. PubMed PMID: 25955459.

21. Steffel J, Verhamme P, Potpara TS, Albaladejo P, Antz M, Desteghe L, Haeusler KG, Oldgren J, Reinecke H, Roldan-Schilling V, Rowell N, Sinnaeve P, Collins R, Camm AJ, Heidbüchel H; ESC Scientific Document Group . The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Eur Heart J. 2018 Apr 21;39(16):1330-1393. doi: 10.1093/eurheartj/ehy136. PubMed PMID: 29562325.

22. Michigan Anticoagulation Quality Improvement Initiative (MAQI2). Anticoagulation Toolkit (Version 1.8). Updated 10/8/2017.

23.Van Spall HG, Wallentin L, Yusuf S, Eikelboom JW, Nieuwlaat R, Yang S, Kabali C, Reilly PA, Ezekowitz MD, Connolly SJ. Variation in warfarin dose adjustment practice is responsible for differences in the quality of anticoagulation control between centers and countries: an analysis of patients receiving warfarin in the randomized evaluation of long-term anticoagulation therapy (RE-LY) trial. Circulation. 2012 Nov 6;126(19):2309-16. doi: 10.1161/CIRCULATIONAHA.

112.101808. Epub 2012 Oct 1. PubMed PMID: 23027801.

24. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007 Jun 19;146(12):857-67. PubMed PMID: 17577005.

25. Erik Lindgren – Cerebral Venous Thrombosis – Complications and Outcomes. Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg. 2022.

26. José M Ferro, Diana Aguiar de Sousa. Cerebral Venous Thrombosis: an Update. Curr Neurol Neurosci Rep. 2019 Aug 23;19(10):74. doi: 10.1007/s11910-019-0988-x.

27. Saposnik G, Barinagarrementeria F, Brown RD, et al. Diagnosis and management of cerebral venous thrombosis: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(4):1158- 1192.

28. Ferro JM, Bousser MG, Canhao P, et al. European Stroke Organisation guideline for the diagnosis and treatment of cerebral venous thrombosis – endorsed by the European Academy of Neurology. Eur J Neurol. 2017;24(10):1203-1213.

29. Клинические протоколы по лечению церебрального венозного тромбоза – РЦРЗ (Республиканский центр развития здравоохранения МЗ РК) – 2019.

30. Фонякин АВ, Гераскина ЛА. Факторы риска, диагностика, лечение и профилактика венозных тромбозов и тромбоэмболий при остром инсульте. Неврология, нейропсихиатрия, психосоматика. 2013;(4):4–9.

31. О.А. Бувина, М.А. Евзельман тромбоэмболия легочной артерии при тяжелом инсульте.  Ученые записки орловского государственного университета. Серия: естественные, технические и медицинские науки. 2012;(3);178-181.

32. Алгоритмы эффективного и безопасного применения антикоагулянтов в стационаре: учебное пособие / Отделёнов В. А., Клеймёнова Е. Б., Сычев Д. А. ГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования». — М.: ФГБОУ ДПО РМАНПО, 2018. 101 с.: ил.

 

Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship. 
Contribution. Article was prepared with equal participation of the authors.
Article received: 15.07.2023. Accepted for publication: 16.08.2023