A.I. BURNASYAN FMBC CLINICAL BULLETIN

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №2 2025 год

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A.I. Burnasyan  FMBC clinical bulletin. 2024 № 4

Y.S. Rusyaykina, A.A. Zavialov

A Clinical Case of Metastatic Colorectal Cancer Associated with a Mutation of the Kras Gene in an Elderly Patient, Taking into Account the Comorbidity Index

International Office, State Research Center – Burnasyan Federal Medical Biophysical Center
of Federal Medical Biological Agency, Moscow, Russiа

Contact person: Rusyaykina Yulia Sergeevna: rysou1@mail.ru

Abstract
In Russia and other developed countries, a colorectal cancer is one of the main causes of deaths from malignant neoplasms. For last ten years a number of patients with colorectal cancer has been growing up each year all around the world. It relates with cancer incidence increase, diagnosis improvement, good treatment results. At the same time, the incidence of colorectal tumors steadily increases with age. Before the start of elderly and senile people anticancer therapy it’s necessary to assess potential risks and ability of positive results achieve.
There is a little information in the literature on usage of complex Comprehensive Geriatric Assessment (CGA), Cancerand Aging Research Group (CARG) toxicity assessment for elderly and senile people before the start of specialized antitumor therapy (chemotherapy).
In this article the author observed a clinical experience of chemotherapy treatment of elderly patient (76 years old) with metastatic colorectal cancer associated with KRAS gene mutation.

Keywords: malignant neoplasms, metastatic colorectal cancer, advanced age, antitumor drug therapy, comorbidity index

For citation: RusyaykinaYS, ZavialovAA. A Clinical Case of Metastatic Colorectal Cancer Associated with A Mutation of the Kras Gene in an Elderly Patient, Taking into Account the Comorbidity Index. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2024.4:20-24. (In Russian) DOI: 10.33266/2782-6430-2024-4-20-24

 

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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship. 
Contribution. Article was prepared with equal participation of the authors.
Article received: 18.08.2024. Accepted for publication: 11.09.2024

© 2025 Scientific journal - "Clinical Bulletin of the FMBС im. A.I. Burnasyan"
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