A.I. BURNASYAN FMBC CLINICAL BULLETIN

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №2 2025 год

more

A.I. Burnasyan  FMBC clinical bulletin. 2025 № 1

K.M. Badykova1, Y.S. Kitaeva2, E.A. Praskurnichij1, E.V. Kuzneczova3, M.A. Butusova1, V.S. Blinov4

Staged Treatment of a Femoral Neck Fracture Due to Osteoporosis Associated
with Hemoblastosis: Description of a Clinical Case Study

1International Office, State Research Center – Burnasyan Federal Medical Biophysical Center  of Federal Medical Biological Agency, Moscow, Russiа

2Department of Analysis and Strategic Planning of the Center for Public Health and Medical Prevention of the FMBA of Russia, Moscow, Russia

3Ural State Medical University, Ministry of Health of the Russian Federation,  Ekaterinburg, Russia

4Verkhnepyshminskaya Central City Hospital named after P.D. Borodin, Sverdlovsk Region, Russia

Contact person: Badykova Kseniya Mikhaylovna: t_astrelina@mail.ru

 

Abstract
Osteoporosis can develop from a variety of conditions. Today, this pathology is increasingly acquiring medical and social significance and is spreading to young people. An important pathogenetic link in drug-induced osteoporosis is pathogenetic therapy in the treatment of hematologic malignancies, such as acute myeloid leukemia. The condition of the bone tissue is influenced by the course of the underlying disease and the toxic effect of chemotherapy, which helps to increase the activity of osteoresorptive processes. The problem of the development of osteoporosis in patients with acute myeloid leukemia after courses of high-dose pathogenetic therapy is very relevant. We describe a clinical case of a patient diagnosed with acute myeloid leukemia who received induction courses of chemotherapy and developed  a closed medial fracture of the right femoral neck as a result of treatment.  After the fracture, the patient received an allogeneic hematopoietic stem cell transplant. The patient received immunosuppressive therapy as part of the prevention of graft-versus-host disease. After transplantation, the patient underwent cemented total hip arthroplasty of the right hip joint. The bone tissue condition in this case was assessed using dual-energy X-ray absorptiometry, according to which the patient had osteopenia/osteoporosis. Despite the severity of the underlying disease, allogeneic hematopoietic stem cell transplantation and ongoing immunosuppressive therapy, the patient underwent surgery satisfactorily, without complications. This clinical case shows the importance of early diagnosis and timely initiation of osteoporosis prevention in this category of patients in order to prevent the development of severe complications.

Keywords: acute myeloid leukemia, osteoporosis, densitometry, pathological fracture, allogeneic hematopoietic stem cell transplantation

For citation: Badykova KM, Kitaeva YS, Praskurnichij EA, Kuzneczova EV, Butusova MA, Blinov VS. Staged Treatment of a Femoral Neck Fracture Due to Osteoporosis Associated with Hemoblastosis: Description of a Clinical Case Study. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2025.1:42-48. (In Russian) DOI: 10.33266/2782-6430-2025-1-42-48

 

REFERENCES

  1. Strukov V.I., Elistratov D.G., Kislov A.I., Strukova-Dzhouns O.V., Eremina N.V., Deryabina G.P. et al. Osteoporoz v geriatricheskoj praktike. Vrach. 2018; 29 (6): 26-30. Russian.
  2. Polozhaeva I.V., Aliyakparov M.T. Aktualnost problemy osteoporoza v molodom vozraste i ego rannej sovremennoj diagnostiki. Mezhdunarodnyj zhurnal prikladnyx i fundamentalnyx issledovanij. 2018; (2): 115-120. Russian.
  3. Ostroumova O.D., Goloborodova I.V. Medicines associated with the development of osteoporosis. Pharmateca. 2020; (4): 108-118. Russian.
  4. Ostroumova O.D., Goloborodova I.V. Drug-induced osteoporosis. Klinicheskaya farmakologiya i terapiya. 2020; 29 (3): 73-79. Russian.
  5. Savchenko V.G., Parovichnikova E.N., ed. Ostrye lejkozy. Klinicheskaya onkogematologiya: rukovodstvo dlya vrachej. 2nd ed., revised and additional. M.: Litterra; 2007. Russian.
  6. Parovichnikova E. N., Troiczkaya V. V., Klyasova G. A., Treating patients with acute myeloid leukemias (AML) according to the protocol of the AML-01.10 Russian multicenter randomized trial: the coordinating center’s results. Ter Arkh. 2014; (7): 14-23. Russian.
  7. Kantarjian H, O’Brien S. Questions regarding frontline therapy of acute myeloid leukemia. Cancer. 2010; 116 (21): 4896-4901.
  8. Vyxovanecz N.Yu., Alyoshechkin P.A., Tomash L.A., Shevchenko A.S., Krasnyanskaya L.A.., Shulik A.I. Rannie i otdalennye nevrologicheskie oslozhneniya ximioterapii v onkologii (obzor literatury). Zlokachestvennye opuxoli. 2022; 12 (4): 41-49. Russian.
  9. Murasheva K. D. Oslozhneniya ximioterapii. Kardiotoksichnost antraciklinovyx antibiotikov. FORCIPE. 2021; №S1: 625-626. Russian.
  10. Balzhanova Ya. B., Sorkina O. M., Grachev A. E., Kanaeva M. L., Nakastoev I. M., Ryzhko V. V. i dr. Porazhenie kostej pri B-kletochnom ostrom limfoblastnom lejkoze. Russian journal of hematology and transfusiology. 2022; №S2: 159. Russian.
  11. Dumanskij Yu. V., Stolyarova O. Yu., Sinyachenko O. V., Egudina E. D. Kostnyj metabolizm i osteoporoz v onkologicheskoj praktike. BSP. 2015; 3 (19): 5-9. Russian.
  12. Kitaeva Yu. S., Badykova K. M., Praskurnichij E. A. An option for the debut of acute lymphoblastic leukaemia with a lesion of the bone system. A description of clinical observation. Bulletin of Siberian Medicine. 2024; 3 (147): 97-101. Russian.
  13. Bagrova S. G., Basin E.M., Valiev A.K., Den`gina N.V., Kopp M.V., Kutukova S.I. et al. Profilaktika i lechenie patologii kostnoj tkani pri zlokachestvennyx novoobrazovaniyax. Zlokachestvennye opuxoli: Prakticheskie rekomendacii RUSSCO. 2022; 12 (3s2): 40–54. Russian.
  14. Ismailov S. I., Xodzhamberdieva D. Sh., Rixsieva N. T. Osteoporoz i nizkoe`nergeticheskie perelomy` shejki bedra kak oslozhnenie razlichnyx endokrinnyx zabolevanij (obzor literatury). International journal of endocrinology. 2013; 5(53): 113-120. Russian.
  15. Mustafakulova N.I., Kamolova G.N., Mirzokarimova N.S., Abdullaeva S.N., Xolova Sh.K. Prognostic value of clinical and radiological parameters of osteoarticular lesions inpatients with leukemia. Neurology, Neuropsychiatry, Psychosomatics. 2019; (3): 262-269. Russian.
  16. Nikolaeva L.P., Cherdancev D.V., Xvat N.S. Osobennosti mielogrammy kostnogo mozga trubchatyx kostej. Sovremennye problemy nauki i obrazovaniya. 2015; (4). Russian.
  17. Skvorczova Yu. V., Balashov D. N., Maschan A.A. Osteopenia and osteoporosis after allogeneic hematopoietic stem cell transplantation, features of bone mineral turnover pathology in children. Pediatric Hematology/Oncology and Immunopathology. 2016; 4(16): 98-106. Russian.
  18. Kolesnichenko L.S., Laletin V.S. Vliyanie protivoopuxolevyx antimetabolitov na sistemu glutationa. BSP. 2006; (7): 50-51. Russian.
  19. Zaxarov I.S., Kolpinskij G.I., Ushakova G.A., Vavin G.V. The role of oxidative stress in the formation of postmenopausal osteoporosis. Gynecology. 2014; 16(1): 41-43. Russian.
  20. Melnichenko G.A., Mamedova E.O. Iatrogenic lesions of the skeleton. Osteoporosis and Bone Diseases. 2017; 20(4): 19-25. Russian.
  21. Grishhuk A.N., Kameka A.L., Leonova S.N. Oslozhneniya pervichnogo e`ndoprotezirovaniya tazobedrennogo sustava. Sovremennye problemy nauki i obrazovaniya. 2023; (6). Russian.

Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 11.09.2024. Accepted for publication: 15.10.2024

© 2025 Scientific journal - "Clinical Bulletin of the FMBС im. A.I. Burnasyan"
Scroll to Top