A.I. BURNASYAN FMBC CLINICAL BULLETIN

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №1, 2026

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A.I. Burnasyan  FMBC clinical bulletin. 2026 № 1

E.А. Praskurnichiy1, Yu.S. Kitayeva2, E.V. Kuznetsova3, E.Y. Sumorokova2, D.V. Kichigina4, O.V. Parinov1

Clinical Appraisal of a prognostic Model for Assessing the Risk of Osteoporosis
in Patients with Hodgkin’s Lymphoma. Description Of Clinical Observations

1International Office, State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russiа
2Russian National Research Medical University named after. N. I.Pirogova, Moscow, Russia
3Federal State Budgetary Institution of Higher Professional Education Urals State Medical University» of the Ministry of Healthcare of the Russian Federation, Department of Propaedeutics of Internal Diseases, Ekaterinburg, Russia
4Federal State Budgetary Institution “Central State Medical Academy” of the Administrative Department of the President of the Russian Federation, Moscow, Russia

Contact person: Yulia Sergeevna Kitaeva: jkhema@yandex.ru

 

Abstract
Osteoporosis in young patients with Hodgkin’s lymphoma receiving pathogenetic therapy is an urgent problem that is often underestimated due to the young age of patients and the lack of obvious clinical symptoms. Antitumor treatment disrupts bone metabolism, requiring timely diagnosis of a decrease in bone mineral density. Two clinical cases of HL in young patients who have achieved remission after polychemotherapy courses are presented. To predict the risk of osteoporosis, the developed mathematical model of logistic regression was used, taking into account the levels of HGH, IGF-1, LH and body area. The use of the model allowed us to determine the high risk of osteoporosis in the first patient, which was confirmed by densitometry. The second patient had a low risk of developing a decrease in bone mineral density, which corresponded to normal values according to densitometry. Densitometry is the golden method of diagnosing BMD, however, in its absence, predictive models based on available indicators can serve as an effective screening tool. The presented cases demonstrate different outcomes with the same treatment regimen, emphasizing the importance of a personalized approach to patients. The use of the model makes it possible to optimize the use of densitometry, using it only in high-risk groups. The use of a mathematical model makes it possible to detail the risk of osteoporosis and implement personalized prevention programs, reducing the likelihood of low-energy fractures, often associated with insufficient alertness of doctors regarding complications of PCT in young people.

Keywords: Hodgkin’s lymphoma, densitometry, osteoporosis, bone mineral density, mathematical model

For citation: Praskurnichiy EA, Kitayeva YuS, Kuznetsova EV, Sumorokova EY, Kichigina DV., Parinov OV. Clinical Appraisal of a prognostic Model for Assessing the Risk of Osteoporosis in Patients with Hodgkin’s Lymphoma. Description Of Clinical Observations. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2026.1:102-108. (In Russian). DOI: 10.33266/2782-6430-2026-1-102-108

 

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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 23.11.2025. Accepted for publication: 25.12.2025

© 2026 Scientific journal - "Clinical Bulletin of the FMBС im. A.I. Burnasyan"
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