A.I. Burnasyan Scientific journal FMBC

Clinical Bulletin

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №1 2024 год

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A.I. Burnasyan  FMBC clinical bulletin. 2022 № 2

Current Achievements and Relevant Tasks of Space Radiobiology
I.B. Ushakov

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Ushakov Igor Borisovich: iushakov@fmbcfmba.ru

Abstract
Purpose: Analytical review of space radiobiology current state and promising areas, revision of space radiobiology crucial tasks were the research objectives.

Material and methods: Data from a chronic experiment on 700 mature male rats (radiation doses of 10-100 sGr), clinical and physiological data of irradiated pilots-liquidators of the Chernobyl accident consequences (more than 1000 people) and numerous radiation neurophysiological experiments, including with heavy charged particles (HCP) were used methodologically as new experimental patterns. The methods are presented in 3 monographs and 19 journal articles.

Results: The main barrier to further human penetration into space is cosmic radiation from various sources: galactic and solar cosmic rays. Complex radiation “cocktails” in space are dangerous, taking into account secondary neutrons and gamma-irradiation. Modeling it on Earth is extremely difficult. The structure of modern space radiobiology includes: radiation situation in near and far space; features of dosimetry in space and the possibility of using various phantoms; multilevel effects of human radiation exposure in space; small doses and the brain; the role of combined effects; elaboration of new approaches for extrapolation on human experimental data obtained on animals; rationing of radiation effects in space, taking into account the numerous non-radiation risks in flight; development of means to increase radioresistance and biomedical protection.

New concept of human radiation safety in orbital flights should take into account all the likely immediate and long-term consequences of human radiation exposure in space. It is necessary to verify possible brain disorders from HCP, taking into account combined effect of other flight factors, including the hypomagnetic environment, and to assess the risk of imminent radiation threats, in particular on the Moon or Mars. Modern science is not yet able to predict solar proton events well, knowledge about the spectra of cosmic radiation and methods for calculating doses during the passage of various types of radiation through matter is limited. The new concept of protection can be called “the concept of choosing a lesser amount of evil”. The principle of ALARA is not canceled, but is put on the verge of possible compliance. In the on-board first aid kit, it is necessary to have means that will be a kind of modern “sum of radiobiology” at the time of flight, using the entire arsenal of countermeasures – radioprotectors, radiomitigators, radio-modulators, hibernation, artificial magnetic field, etc. The crew should be selected from the most radio-resistant astronauts (according to geno- and phenotypic criteria).

Conclusion: Modern space radiobiology is at a critical stage of finding new ways of development and obtaining breakthrough results.

Keywords: space radiobiology, space radiation, neuroradiobiology, radiation physiology, ionizing radiation and the brain, extrapolation of radiobiological effects, long-term space flights, models of interplanetary expeditions, limits of radiation exposure in space

For citation: Ushakov I.B. Current Achievements and Relevant Tasks of Space Radiobiology. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2022.2:26-33. (In Russian) DOI: 10.33266/2782-6430-2022-2-26-33

REFERENCES

  1. Grigoryev Yu.G., Ushakov I.B., Krasavin Ye.A., Davydov B.I., Shafirkin A.V. Kosmicheskaya Radiobiologiya za 55 Let = Space Radiobiology for 55 Years. Moscow, Ekonomika Publ., 2013. 303 p. (In Russ.).
  2. Shafirkin A.V., Grigoryev Yu.G. Mezhplanetnyye i Orbitalnyye Kosmicheskiye Polety. Radiatsionnyy Risk dlya Kosmonavtov (Radiobiologicheskoye Obosnovaniye) = Interplanetary and Orbital Space Flights. Radiation Risk for Astronauts (Radiobiological Justification). Moscow, House Ekonomika Publ., 2009. 639 p. (In Russ.).
  3. Ivanov I.V., Ushakov I.B. Basic Approaches to the Extrapolation of Data of Animals to Human in Radiobiological. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2020;65;3:5-12. DOI: 10.12737/1024-6177-2020-65-3-5-12 (In Russ.).
  4. Vasin M.V., Ushakov I.B. Radiomodulators as Agents of Biological Protection Against Oxidative Stress under the Influence of Ionizing Radiation. Biology Bulletin Reviews. 2020;10;4:251-265. DOI: 10.1134/S2079086420040106.
  5. Betts K.V., Bukhtiyarov I.V., Tikhonova G.I., Ushakov I.B., Voronkov Yu.I. Spaceflight Duration and the Mortality of Cosmonauts: Abstracts XXIII International Symposium “Human in Space” Moscow, 5-9 April, 2021. Aerospace and Environmental Medicine. 2021;55;1/1 (special issue):20.
  6. Shafirkin A.V., Grigoryev Yu.G., Ushakov I.B., Shurshakov V.A. Biological Effectiveness of Fast Neutrons and a Celerated Multicharged Ions for Derivation of a New Dependence of Space Radiation Quality Coefficients on Linear Energy Transfer. Aviakosmicheskaya i Ekologicheskaya Meditsina = Aerospace and Environmental Medicine. 2021;55;3:5-15. DOI: 10.21687/0233-528X-2021-55-3-5-15 (In Russ.).
  7. Vidnyye Otechestvennyye Uchenyye v Oblasti Radiobiologii, Radiatsionnoy Meditsiny i Bezopasnosti (Biobibliograficheskiy Spravochnik) = Prominent Russian Scientists in the Field of Radiobiology, Radiation Medicine and Safety (Biobibliographic Reference Book). Ed. Ilin L.A., Samoylov A.S., Ushakov I.B. Moscow, A.I. Burnasyan FMBC Publ, 2021. 616 p. (In Russ.).
  8. Ushakov I.B., Fedorov V.P. Radiation Risks of Helicopter Personnel Responding to the Chernobyl Accident: Early and Long-Term Health Disorders. Meditsina katastrof = Disaster medicine. 2021;3:52-57. DOI: 10.33266/2070-1004-2021-3 (In Russ.).
  9. Ushakov I.B., Fedorov V.P. Changes in the Cortex Neurons in Single and Fractional Gamma Radiation. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2021;66;4:18-24. DOI: 10.12737/1024-6177-2021-66-4-18-24 (In Russ.).
  10. Ushakov I.B. Kosmos. Radiatsiya. Chelovek: (Radiatsionnyy Baryer v Mezhplanetnykh Poletakh) = Cosmos. Radiation. Man (Radiation barrier in interplanetary flights). Monograph. Moscow, Nauchnaya Kniga Publ., 2021. 352 p. (In Russ.).
  11. Rogozhnikov V.A., Ushakov I.B., Grigoryev Yu.G., Bushmanov A.YU., Shafirkin A.V., Abrosimova A.N., Shurshakov V.A., Sakovich V.A., Soldatov S.K. Ogranicheniye Oblucheniya Kosmonavtov pri Okolozemnykh Kosmicheskikh Poletakh (OOKOKP-2021) = Limitation of Cosmonauts’ Radiation Exposure During Near-Earth Space Flights (OOKOCP-2021). Methodological Recommendations of MR FMBA 17.01-2021. Moscow, Roscosmos Publ., 2021. 44 p. (In Russ.).
  12. Shtemberg A.S., Lebedeva-Georgievskaya K.B., Matveeva M.I., Kudrin V.S., Narkevich V.B., Klodt P.M., Bazyan A.S. Effect of Space Flight Factors Simulated in Ground-Bazed Experiments on the Behavior, Discriminant Learning, and Exchange of Monoamines in Different Brain Structures of Rats. Biol. Bull. 2014;41;2:161-167. DOI: 10.7868/S0002332914020118.
  13. Shtemberg A.S., Kokhan V.S., Kudrin V.S., Matveeva M.I., Lebedeva-Georgievskaya K.B., Timoshenko G.N., Molokanov A.G., Krasavin E.A., Narkevich V.B., Klodt P.M., Bazyan A.S. The Effect of High-Energy Protons in Bragg Peak on the Exchange of Monoamines in some Brain Structures. Neurochemical Journal. 2015;9;1:66-72. DOI: 10.7868/S1027813315010100.
  14. Shtemberg A.S., Perevezentsev A.A., Lebedeva-Georgievskaya K.B., Mitrofanova O.V., Kudrin V.S. and Bazyan A.S. The Role of Typological Characteristics of Higher Nervous Activity in Rats in the Neurobiological Effects of Combined Exposure to an Antiorthostatic Suspension, Gamma-Rays, Protons, and Carbon 12C Ions. Biology Bulletin. 2020;47;11:37-45. DOI: 10.1134/S1062359020110138.
  15. Shtemberg A.S. The Problems of Experimental Investigation of Spaceflight Factors Combined Influence on Animals Organism Functions. Rossiyskiy Fiziologicheskiy Zhurnal Imeni I.M. Sechenova = Russian Journal of Physiology. 2014;100;10:1152-1168 (In Russ.).

Conflict of interest. The authors declare no conflict of interest. 
Financing. The study had no sponsorship. 
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.01.2022. Accepted for publication: 01.02.2022

 

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