A.I. Burnasyan Scientific journal FMBC

Clinical Bulletin

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №2 2022 год

A.I. Burnasyan  FMBC clinical bulletin. 2022 № 1

Risk Factors for Purious-Septic Incidence in Newborn
D.Yu. Karimova, A.N. Plutnitsky, R.R. Averchenko, O.Yu. Dokuchaeva, M.K. Alsabekova
A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Karimova D.Yu., dania_karimova@mail.ru

Abstract
Purpose: Identification of biomedical and socio-economic factors contributing to the development of sepsis and pyoinflammatory diseases in newborns.
Material and Methods: Using specially designed questionnaires, we analyzed hospital records, extracts from the history of childbirth, and collected information about 460 children. Of these, 282 children had a septic process and 98 had local pyoinflammatory diseases (pyoderma, omphalitis, etc.). The control group consisted of 80 children who did not get sick until 6 months of age.
For mathematical processing of the collected material, Pearson’s goodness-of-fit test x2 was used.
Results:In both groups of patients, the influence of such social and hygienic factors as the material security of the family (x2 = 21,1; p<0,001 and x2 =15,37; p<0,01), maternal malnutrition during pregnancy (x2 = 33,6; p<0,001 and x2 =11,3; p<0,01), while unfavorable living conditions and crowding prevailed only in the group of septic patients: x2 = 4,15; p<0,05 and x2=1,26; p<0,05.
As a rule, mothers of children who fell ill with sepsis in the neonatal period were not regularly observed during pregnancy in the antenatal clinic (x2 = 10,9; p<0,001). In the group of children with local processes, this is not reliably traced (x2 = 1,09; p> 0,05).
Where mothers did not rest during maternity leave or did not use it at all due to premature birth, both diseases occurred: x2 = 3,8; x2 = 6,32; p<0,05.
We also revealed the effect of gynecological, in particular, chronic inflammatory diseases of the mother (x2 = 9,53; p<0,01), abortions preceding pregnancy with this fetus (x2 = 5,01; p<0,05) on septic morbidity in newborns, and in the group of children with local purulent-inflammatory diseases, the results are not reliable, respectively: x2 = 2,82; x2 = 1,4; p>0,05.
According to our data, the effect of benefits during delivery on the purulent-septic morbidity  of  newborns is  not traced (x2 = 0,01; x2 = 5,5; p>0,05), but there is a clear connection with the weakness of labor activity, protracted childbirth (x2=10,7; p<0,001; x2=8.53; p<0,01). Meanwhile, rapid delivery, although generally unfavorable for the child, we have not established a significant impact on the occurrence of sepsis in newborns (x2 = 3,4; p>0,05).
The association of septic and pustular morbidity in newborns with the duration of the anhydrous period with premature discharge of amniotic fluid (x2 = 18,07; x2 = 21,46; p<0,001), as well as with fetal asphyxia during childbirth (x2 = 14,63; p<0,01; x2=14,1; p<0,001).
Attention is drawn to the significant impact on the occurrence of local purulent-inflammatory diseases in newborns of an unfavorable psychological climate of the family (less attention is paid to the child, care for him suffers) – x2 = 7,65; p<0,05. The reliability of the influence of this factor in the group of children with sepsis is even higher: x2 = 17,52; p<0,001. Very often, patients with sepsis are illegitimate children (x2 = 6,65; p<0,01), or children whose appearance in the family for one reason or another was temporarily undesirable (x2 = 7,14; p<0,01), which is not observed where the disease proceeded easily, in the form of a local purulent-inflammatory process (respectively: x2 = 3,0; x2 = 0,9; p>0,05).
The article also discusses a number of other biomedical and social factors affecting the purulent-septic morbidity of newborns.
These data allow us to identify the contingent of newborns predisposed to this pathology, and to develop measures for their prevention.
Keywords: newborns, pyoinflammatory diseases, sepsis, risk factors
For citation: Karimova, DYu,  Plutnitsky AN, Averchenko RR, Dokuchaeva OYu, Aslabekova MK. Risk Factors for Purious-Septic Incidence in Newborn A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2022.1:35-39. (In Russ.) DOI: 10.33266/2782-6430-2022-1-31-35

REFERENCES
1. Шабалов, Н.П. Неонатология [Текст]: учеб, пособие : в 2-х т. / Н.П. Шабалов. – 6-е изд, испр. и доп. – М. : ГЭОТАР-Медиа, 2016. – Т.1. – 928 с.

2. Шабалов, Н.П. Неонатология [Текст]: учеб, пособие : в 2-х т. / Н.П. Шабалов. – 6-е изд, испр. и доп. – М. : ГЭОТАР-Медиа, 2016. – Т.2. – 880 с.
3. Практические умения в неонатологии [Текст] : учеб.-метод, пособие / сост. В. О. Быков, О. С. Корниенко, Е. В. Кулакова, М. С. Пустобаева. – Ставрополь : Изд-во СтГМУ, 2018. – 92с
4. Сотникова К.А., Вельтищев Ю.Е. В сб. научных трудов Москов. НИИ пед. и дет.хир. в.4, М.,1976, 157 с.
5. Hemming V.G., Mc Closkey D.W., Hill H.R. – Amer. J.Dis.Chld., 1976, 130, №11, 1231 – 1233
6. Tollner U., Pohlandt F. – Europ. J.Pediat., 1976, 123, №4, 243 -254.
7. Monnet P.Pediatrie (Lion), 1976, 31, №2, 135-154.
8. Lando M.E. Social Security Bulletin, 1975, 38, № 12, 16-23.
9. Куриленко Л .И., Волков И.М., Есиков М.С. Ж. Совет. здравоохр., 1975, № 10, с.27-33.
10. Рооз, Р. Неонатология. Практические рекомендации [Текст] : справ. / Р. Рооз, О. Генцель-Боровичени, Г. Прокитте; пер. с нем. С.Н. Коваль, Е.В. Суслина, П.В. Шевченко [и др.] ; ред. пер. Р. Вауэр, Г.А. Шишко. – М. : Медицинская литература, 2013.-592 с.
11. Справочник педиатра [Текст] / под ред. В.О. Быкова, А.С. Калмыковой. – 4-е изд., перераб. и доп. – Ростов н/Д. : Феникс, 2015. – 605 с.
12.  Bergvist G., Eriksson M., Zetterstrom R. – Acta paediat.scand., 1979, 68, №3, 337 – 339.
13. Hohenauer L., Wilk F. – Z.Geburtsh. Perinat., 1977, 181, №1, 55 – 58.
14. Полин, Р.А. Секреты неонатологии и перинатологии [Текст] / Р.А. Полин, А.Р. Спитцер ; пер. с англ, под общ. ред. Н.Н. Володина. – М. : БИНОМ, 2013.-624 с.
15. Сайт Российского общества неонатологов – URL: http://neonatology.pro
16. Сайт Российской ассоциации специалистов перинатальной медицины – URL: http://www.raspm.ru

Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.01.2022.  Accepted for publication: 01.02.2022 

 

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