A.I. Burnasyan  FMBC clinical bulletin. 2022 № 2

Risk Factors for Purious-Septic Incidence in Newborn
D.Yu. Karimova, A.N. Plutnitsky, R.R. Averchenko, O.Yu. Dokuchaeva

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: D.Yu. Karimova: dania_karimova@mail.ru

Abstract
Purpose: Identification of biomedical and socio-economic factors contributing to the development of sepsis and pyoinflammatory diseases in newborns.

Material and Methods: Using specially designed questionnaires, we analyzed hospital records, extracts from the history of childbirth, and collected information about 460 children. Of these, 282 children had a septic process and 98 had local pyoinflammatory diseases (pyoderma, omphalitis, etc.). The control group consisted of 80 children who did not get sick until 6 months of age.

For mathematical processing of the collected material, Pearson’s goodness-of-fit test χ2 was used.

Results: In both groups of patients, the influence of such social and hygienic factors as the material security of the family (χ2 = 21,1; p<0,001 and χ2 =15,37; p<0,01), maternal malnutrition during pregnancy (χ2 = 33,6; p<0,001 and χ2 =11,3; p<0,01), while unfavorable living conditions and crowding prevailed only in the group of septic patients: χ2 = 4,15; p<0,05 and χ2=1,26; p<0,05.
As a rule, mothers of children who fell ill with sepsis in the neonatal period were not regularly observed during pregnancy in the antenatal clinic (χ2 = 10,9; p<0,001). In the group of children with local processes, this is not reliably traced (χ2 = 1,09; p> 0,05).
Where mothers did not rest during maternity leave or did not use it at all due to premature birth, both diseases occurred: χ2 = 3,8; χ2 = 6,32; p<0,05.
We also revealed the effect of gynecological, in particular, chronic inflammatory diseases of the mother (χ2 = 9,53; p<0,01), abortions preceding pregnancy with this fetus (χ2 = 5,01; p<0,05) on septic morbidity in newborns, and in the group of children with local purulent-inflammatory diseases, the results are not reliable, respectively: χ2 = 2,82; χ2 = 1,4; p>0,05.
According to our data, the effect of benefits during delivery on the purulent-septic morbidity of newborns is not traced (χ2 = 0,01; χ2 = 5,5; p>0,05), but there is a clear connection with the weakness of labor activity, protracted childbirth (χ2=10,7; p<0,001; χ2=8.53; p<0,01). Meanwhile, rapid delivery, although generally unfavorable for the child, we have not established a significant impact on the occurrence of sepsis in newborns (χ2 = 3,4; p>0,05).
The association of septic and pustular morbidity in newborns with the duration of the anhydrous period with premature discharge of amniotic fluid (χ2 = 18,07; χ2 = 21,46; p<0,001), as well as with fetal asphyxia during childbirth (χ2 = 14,63; p<0,01; χ2=14,1; p<0,001).
Attention is drawn to the significant impact on the occurrence of local purulent-inflammatory diseases in newborns of an unfavorable psychological climate of the family (less attention is paid to the child, care for him suffers) – χ2 = 7,65; p<0,05. The reliability of the influence of this factor in the group of children with sepsis is even higher: χ2 = 17,52; p<0,001. Very often, patients with sepsis are illegitimate children (χ2 = 6,65; p<0,01), or children whose appearance in the family for one reason or another was temporarily undesirable (χ2 = 7,14; p<0,01), which is not observed where the disease proceeded easily, in the form of a local purulent-inflammatory process (respectively: χ2 = 3,0; χ2 = 0,9; p>0,05).
The article also discusses a number of other biomedical and social factors affecting the purulent-septic morbidity of newborns.
These data allow us to identify the contingent of newborns predisposed to this pathology, and to develop measures for their prevention.

Keywords: newborns, pyoinflammatory diseases, sepsis, risk factors

For citation: Karimova DYu, Plutnitsky AN, Averchenko RR, Dokuchaeva OYu. Risk Factors for Purious-Septic Incidence in Newborn. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2022.2:49-53. (In Russian) DOI: 10.33266/2782-6430-2022-2-49-53

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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship. Участие авторов. 
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.01.2022. Accepted for publication: 01.02.2022