A.I. BURNASYAN FMBC CLINICAL BULLETIN

ISSN 2782-6430 (print)

State Research Center −Burnasyan Federal Medical Biophysical
Center of Federal Medical Biological Agency

The journal is published in Russian.
Format – A4.
The periodicity of the journal is 4 times a year.

Issue №3, 2026

more

A.I. Burnasyan  FMBC clinical bulletin. 2026 № 3

Z.O. Ivanova1, R.A. Akhkubekov1, L.A. Shitova2, A.M. Kaddumi1.

The Study of the Indicators of the Prooxidant System of Blood and Antioxidant Activity in Patients with Post-Traumatic Peritonitis

1Medical Academy of Kabardino-Balkarian State University named after H.M.Berbekova, Nalchik, Russian Federation

2Saint Petersburg State Pediatric Medical University of the Russian Ministry of Health, St. Petersburg, Russian Federation

Contact person: Ivanova Zolina Olegovna: ivanovazalina@icloud.com

 

Abstract
Introduction: the study of changes in the indicators of blood lipid peroxidation, the activity of the antioxidant system of the blood in post-traumatic peritonitis, to assess the immune reactions of the body, can help to better understand the entire immune response in post-traumatic peritonitis, which can be used in the future in diagnosis, which is important for assessing the dynamics of treatment of patients with this pathology.

Аim: to study the indicators of the pro-oxidant system of the blood and the antioxidant activity of the blood to assess the body’s immune reactions in patients with posttraumatic peritonitis.

Material and methods: the study included 64 patients aged 24 to 73 years. The inclusion criteria were: age over 18 years, 2 criteria for systemic inflammation syndrome or more, clinical signs of posttraumatic peritonitis and the results of additional research methods. The exclusion criteria were the presence of an unsanitized focus of surgical infection, ongoing bleeding.

Results and discussion: patients were found to have a significant increase in the level of MDA (5.8 μmol/l), an increase in the activity of the spontaneous NBT test (65 %), the content of catalase in erythrocytes (53 mmol/min*gHb), SOD in patients 6.2 u/ml and a decrease in the content of ceruloplasmin (252 mg/l).

Findings: fs a result of this study, patients with posttraumatic peritonitis were found to have an increased production of a complex of both pro-inflammatory and anti-inflammatory cytokines with their rapid and excessive intake into the peripheral blood, as well as a significant increase in the level of MDA, an increase in the activity of a spontaneous NВT test of the catalase content in erythrocytes, and a decrease in the content of ceruloplasmin.

Keywords: antioxidant activity of blood, cytokine profile, oxidative stress, posttraumatic peritonitis

For citation: Ivanova ZO, Akhkubekov RA, Shitova LA. The Study of the Indicators of the Prooxidant System of Blood and Antioxidant Activity in Patients with Post-Traumatic Peritonitis. A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin. 2026.3:102-108. (In Russian) DOI: 10.33266/2782-6430-2026-3-102-108

 

REFERENCES

  1. Gaoussou S., Drissa K., Goundo S., et al. Post-Traumatic Peritonitis in the General Surgery Departement of the Fousseyni Daou Hospital in Kayes, Mali. SAS J Surg. 2024 Jan 10;1:136-142.
  2. Doh Sylla M. Perforation Digestives Traumatiques Dans le Service de Chirurgie Générale Del’hôpital de Ségou Thèse Med. USTTB. Bamako (Mali). 2021;21:M228.
  3. Gupta S., Zingade A., Baviskar M., et al. Efficacy of the Mannheim Peritonitis Index (MPI) in Predicting Postoperative Outcomes in Patients with Perforation Peritonitis. Cureus. 2025 April 29;17;4:e83193. Doi: 10.7759/cureus.83193.
  4. Huang J., Ren J., McKee J.L., Kirkpatrick A.W. 2023 Updates on the Closed or Open After-Source Control for Severe Complicated Intraabdominal Sepsis (COOL) Trial. World J Surg Infect. 2022;1:47-9.
  5. Sartelli M., Tascini C., Coccolini F., et al. Management of Intra-Abdominal Infections: Recommendations by the Italian Council for the Optimization of Antimicrobial Use. World J Emerg Surg. 2024;19:23. Doi: 10.1186/s13017-024-00551-w.
  6. Mazuski J.E., Symons W.J., Jarman S., Sato B., Carroll W., Bochicchio G.V., Kirby J.P., Schuerer D.J. Reduction of Surgical Site Infection After Trauma Laparotomy Through Use of a Specific Protocol for Antibiotic Prophylaxis. Surg Infect (Larchmt). 2023 Mar;24;2:141-157. Doi: 10.1089/sur.2022.393. PMID: 36856586; PMCID: PMC9983134.
  7. Guevara-Kissel M.F., Egbuonu K., Valdivieso S., et al. A Novel Approach to the Management of an Intra-abdominal Abscess: a Case Report and Literature Review. Cureus. 2025 January 26;17;1:e78022. Doi: 10.7759/cureus.78022.
  8. Georgescu A.M., Szederjesi J., Voidazan S., et al. Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) – a Possible Biomarker for Bacteremia in Sepsis. Rev Romana Med Lab. 2015;23;1:59-73.
  9. Prauchner C.A. Oxidative Stress in Sepsis: Pathophysiological Implications Justifying Antioxidant Co-Therapy. Burns. 2017;43:471–485.
  10. Kumar S., Saxena J., Srivastava V.K., Kaushik S., Singh H., Abo-EL-Sooud K., Abdel-Daim M.M., Jyoti A., Saluja R. The Interplay of Oxidative Stress and ROS Scavenging: Antioxidants as a Therapeutic Potential in Sepsis. Vaccines. 2022;10:1575. Doi: 10.3390/vaccines10101575.
  11. Ватазин А.В., Фомин А.М., Круглов Е.Е., Зулькарнаев А.Б. Послеоперационный перитонит. Хирургические концепции и методы экстракорпоральной гемокоррекции. М.: Бином, 2014. 416 с. [Vatazin A.V., Fomin A.M., Kruglov Ye.Ye., Zul’karnayev A.B. Posleoperatsionnyy Peritonit. Khirurgicheskiye Kontseptsii i Metody Ekstrakorporal’noy Gemokorrektsii = Postoperative Peritonitis. Surgical Concepts and Methods of Extracorporeal Hemocorrection. Moscow, Binom Publ., 2014. 416 p. (In Russ.)].
  12. Roychoudhury S., Chakraborty S., Choudhury A.P., Das A., Jha N.K., Slama P., et al. Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction. Antioxidants. 2021;10;6:837. Doi: 10.3390/antiox10060837.
  13. Guevara-Kissel M.F., Egbuonu K., Valdivieso S., et al. A Novel Approach to the Management of an Intra-abdominal Abscess: a Case Report and Literature Review. Cureus. 2025 January 26;17;1:e78022. Doi: 10.7759/cureus.78022.
  14. Pathak A.A., Agrawal V., Sharma N., et al. Prediction of Mortality in Secondary Peritonitis: a Prospective Study Comparing p-POSSUM, Mannheim Peritonitis Index, and Jabalpur Peritonitis Index. Perioper Med. 2023;12:65. Doi: 10.1186/s13741-023-00355-7.
  15. Osterwalder I., Özkan M., Malinovska A., Nickel C.H., Bingisser R., Osterwalder, et al. Acute Abdominal Pain: MissedDiagnoses, Extra-Abdominal Conditions, and Outcomes. J Clin Med. 2023;12;4:1403. Doi: 10.3390/jcm12041403. PMID: 36836243.
  16. Roberts D.J., Bobrovitz N., Zygun D.A., Ball C.G., Kirkpatrick A.W., Faris P.D., Brohi K., D’Amours S., Fabian T.C., Inaba K., Leppäniemi A.K., Moore E.E., Navsaria P.H., Nicol A.J., Parry N., Stelfox H.T. Indications for Use of Damage Control Surgery in Civilian Trauma Patients: a Content Analysis and Expert Appropriateness Rating Study. Ann Surg. 2016;263:1018-1027. Doi: 10.1097/SLA.0000000000001347. PMID: 26445471.
  17. Bonne S., Sheikh F. Controversies in Surgery: Trauma. Surg Clin North Am. 2021;101:1111-1121. Doi: 10.1016/j.suc.2021.06.008. PMID: 34774272.
  18. Mazuski J.E., Tessier J.M., May A.K., Sawyer R.G., Nadler E.P., Rosengart M.R., Chang P.K., O’Neill P.J., Mollen K.P., Huston J.M., Diaz J.J. Jr, Prince J.M. The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection. Surg Infect (Larchmt). 2017;18:1-76. Doi: 10.1089/sur.2016.261. PMID: 28085573.
  19. Chen Q., Zhu T., Liu J.K., Ding J., Chen L. Conservative Management of Multi-Trauma Induced Peritonitis: Experience, Outcomes, and Indications. World J Clin Cases. 2023;11;25:5897-5902
  20. Liu M., Silva-Sanchez A., Randall T.D., Meza-Perez S. Specialized Immune Responses in the Peri-Toneal Cavity and Omentum. J Leukoc Biol. 2021;109:717–729. Doi: 10.1002/JLB.5MIR0720-271RR.
  21. Rakoto-Ratsimba H.N., Rakotoarivony S.T., Rakotomena S.D., Randriamiarana J.M. Aspects Épidémiologiques des Traumatismes Abdominaux par Accident de Circulation au Centre Hospitalier Universitaire d’Antananarivo. Revue Tropicale de Chirurgie. 2008;8:18-21.
  22. Reche F., Brunot A., Badic B. Outcome of Emergency Embolization in the Non-Operative Treatment of Blunt Trauma of the Spleen: Multicenter Etrospective Study of 52 Cases. Eur J Trauma Emerg Surg. 2010;10:63.
  23. Droge W. Free Radicals in the Physiological Control of Cell Function. Physiol Rev. 2002;82:47–95.
  24. Kumar S., Saxena J., Kumar V.S., Kaushik S., Singh H., Abo-EL-Sooud K., Abdel-Daim M.M., Jyoti A., Saluja R. The Interplay of Oxidative Stress and ROS Scavenging: Antioxidants as a Therapeutic Potential in Sepsis. Vaccines. 2022;10:1575.
  25. Kangari P., Zarnoosheh Farahany T., Golchin A., Ebadollahzadeh S., Salmaninejad A., Mahboob S.A., et al. Enzymatic Antioxidant and Lipid Peroxidation Evaluation in the Newly Diagnosed Breast Cancer Patients in Iran. Asian Pac J Cancer Prev. 2018;19:3511–5. Doi: 10.31557/APJCP.2018.19.12.3511.
  26. Anwar S., Alrumaihi F., Sarwar T., Babiker A.Y., Khan A.A., Prabhu S.V., Rahmani A.H. Exploring Therapeutic Potential of Catalase: Strategies in Disease Prevention and Management. Biomolecules. 2024;14:697. Doi: 10.3390/biom14060697.
  27. Wiggins J.E., Goyal M., Wharram B.L., Wiggins R.C. Antioxidant Ceruloplasmin is Expressed by Glomerular Parietal Epithelial Cells and Secreted into Urine in Association with Glomerular Aging and High-Calorie Diet. J Am Soc Nephrol. 2006 May;17;5:1382-7. Doi: 10.1681/ASN.2005111239. Epub 2006 Apr 5. PMID: 16597684.
  28. Bakhautdin B., Febbraio M., Goksoy E., de la Motte C.A., Gulen M.F., Childers E.P., Hazen S.L., Li X., Fox P.L. Protective Role of Macrophage-Derived Ceruloplasmin in Inflammatory Bowel Disease. Gut. 2013 Feb;62;2:209-19. Doi: 10.1136/gutjnl-2011-300694. Epub 2012 Feb 16. PMID: 22345661; PMCID: PMC3595056.
  29. Noor R., Mittal S., Iqbal J. Superoxide Dismutase-Applications and Relevance to Human Diseases. Med Sci Monit. 2002;8:RA210–5.
  30. Helan M., Malaska J., Tomandl J., Jarkovsky J., Helanova K., Benesova K., Sitina M., Dastych M., Ondrus T., Pavkova Goldbergova M., et al. Kinetics of Biomarkers of Oxidative Stress in Septic Shock: a Pilot Study. Antioxidants. 2022;11:640. Doi: 10.3390/ antiox11040640.

Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship. 
Contribution. Article was prepared with equal participation of the authors.
Article received: 23.05.2026. Accepted for publication: 15.06.20226

© 2026 Scientific journal - "Clinical Bulletin of the FMBС im. A.I. Burnasyan"
Scroll to Top